SPK-843, a new polyene antifungal, possessed efficacy in a murine model of systemic infection caused by Cryptococcus neoformans. The administration of 4.0 mg/kg SPK-843 led to better survival prolongation and fungal reduction than those observed with the administration of 0.7 mg/kg amphotericin B and 80 mg/kg fluconazole (P < 0.001), without histopathological renal changes.

SPK-843, a new polyene antifungal, exhibited dose-dependent efficacy on murine pulmonary aspergillosis models. SPK-843 doses of higher than 1.0 mg/kg of body weight exhibited no renal toxicities and a tendency toward better survival prolongation than the estimated maximum tolerated doses of amphotericin B (Fungizone) (1.0 mg/kg) and liposomal amphotericin B (AmBisome) (8.0 mg/kg).

Igor Tchivilev, Nageswara R. Madamanchi, Aleksandr E. Vendrov, Xi-Lin Niu, and Marschall S. Runge Department of Medicine, Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, North Carolina 27599-7126 Running Title: PP1cγ1 regulates apoptosis in vascular smooth muscle cells 1 Both authors contributed equally to this work. *Address for Correspondence:Marschall S. Ru...

the aim of this research was to compare more and less competitiveness of rice cultivars against barnyardgrass for light extinction coefficient and canopy structur. a filed experiment was conducted in 2007 growing season in tonekabon’s rice research station in mazandaran province. the experiment layout was a factorial design with four randomized complete blocks. seven rice cultivars (khazar, sep...

Copyright: © 2015 Hilton EJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. *Corresponding author: Latha Hebbar, Department of Anesthesia and Perioperative Medicine, Medical University of South Carolin...