نتایج جستجو برای: رزوناتور با مدچندگانه mmr
تعداد نتایج: 672710 فیلتر نتایج به سال:
Kristen rat sarcoma viral oncogene homolog (KRAS) and microsatellite instability (MSI) are prognostic markers of colorectal cancer (CRC). However, the clinical value is still not fully understood, when giving the consideration to both the molecular makers. Five hundred fifty-one patients with CRC were retrospectively assessed by determining their clinicopathological features. KRAS mutations wer...
Previous studies in our laboratory have described increased and preferential radiosensitization of mismatch repair-deficient (MMR(-)) HCT116 colon cancer cells with 5-iododeoxyuridine (IUdR). Indeed, our studies showed that MMR is involved in the repair (removal) of IUdR-DNA, principally the G:IU mispair. Consequently, we have shown that MMR(-) cells incorporate 25% to 42% more IUdR than MMR(+)...
AIM Some retrospective studies have shown a lack of benefit of 5-fluorouracil (5-FU) adjuvant chemotherapy in patients with mismatch repair (MMR) deficient colorectal cancer. Our aim was to assess if this molecular marker can predict benefit from 5-FU adjuvant chemotherapy. A second objective was to determine if MMR status influences short term survival. METHODS We included 754 patients with ...
Eukaryotic mismatch repair (MMR) utilizes single-strand breaks as signals to target the strand to be repaired. DNA-bound PCNA is also presumed to direct MMR. The MMR capability must be limited to a post-replicative temporal window during which the signals are available. However, both identity of the signal(s) involved in the retention of this temporal window and the mechanism that maintains the...
رزوناتورها از جمله قطعات پرکاربردی هستند که برای کاهش صدا مورد استفاده قرار می گیرند و در میان انواع کنترل کننده های صوتی، جزو سیستم های جاذب صوت و صدا خفه کن ها تقسیم بندی می شوند. با توجه به این که در کشور ما زمین های کشاورزی و مناطق مسکونی نزدیک یکدیگر هستند، آلودگی صوتی ناشی از فعالیت تراکتورها به عنوان یکی از فاکتورهای خطر بیماری های مربوط به گوش انسان مطرح است بنابراین نیاز به طراحی نوعی ...
Mismatch Repair (MMR) is closely linked to DNA replication; however, other than the role of the replicative sliding clamp (PCNA) in various MMR functions, the linkage between DNA replication and MMR has been difficult to investigate. Here we use an in vitro DNA replication system based on simian virus 40, to investigate MMR recruitment to replicating DNA. Both DNA replication and MMR proteins a...
wnloaded mismatch repair (MMR) pathway is involved in the removal of DNA base mismatches that arise during DNA replication or are caused by DNA damage. Mutations in four genes involved in MMR, , MLH1, PMS2 and MSH6, predispose to a range of tumorigenic conditions, including hereditary lyposis colon cancer, also known as Lynch syndrome. Here we discuss the canonical MMR pathway e burgeoning evid...
The phenomenon of alkylation tolerance has been observed in cells that are deficient in some component of the DNA mismatch repair (MMR) system. An alkylation-induced cell cycle arrest had been reported previously in one MMR-proficient cell line, whereas a MMR-defective clone derived from this line escapes from this arrest. We examined human cancer cell lines to determine if the cell cycle arres...
background and aims: the safe, potent and effective live vaccines against measles, mumps and rubella as important childhood diseases have been available for several decades. several factors can affect the thermal stability of lyophilized vaccine. methods: in this study, the effect of residual moisture on thermal stability of 61 batches of mmr vaccine was investigated using an accelerated method...
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