نتایج جستجو برای: ردیاب درجه دوم خطی lqt
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Mutations in HERG are associated with human chromosome 7-linked congenital long QT (LQT-2) syndrome. We used electrophysiological, biochemical, and immunohistochemical methods to study the molecular mechanisms of HERG channel dysfunction caused by LQT-2 mutations. Wild type HERG and LQT-2 mutations were studied by stable and transient expression in HEK 293 cells. We found that some mutations (Y...
One quarter of deaths associated with Rett syndrome (RTT), an X-linked neurodevelopmental disorder, are sudden and unexpected. RTT is associated with prolonged QTc interval (LQT), and LQT-associated cardiac arrhythmias are a potential cause of unexpected death. The standard of care for LQT in RTT is treatment with β-adrenergic antagonists; however, recent work indicates that acute treatment of ...
Long QT syndrome (LQTS) is a disorder of ventricular myocardial repolarization characterized by a prolonged QT interval on the electrocardiogram (ECG). At least 12 different genes in patients with congenital LQTS have been described, designated LQT 1 through 12. However, more recently at least 13 types of congenital LQTS have been identified. The neonate, who was born prematurely, was noted to ...
Beta-adrenergic receptor stimulation increases heart rate and shortens ventricular action-potential duration, the latter effect due in part to a cAMP-dependent increase in the slow outward potassium current (I(Ks)). Mutations in either KCNQ1 or KCNE1, the I(Ks) subunits, are associated with variants (LQT-1 and LQT-5) of the congenital long QT syndrome. We now show that cAMP-mediated functional ...
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فرض کنید (g,+,m,m) یک گروه اندازه پذیر، کامل، آبلی بطوریکه اندازه g متناهی و e یک فضای باناخ باشد. برای هر تابع f عملگرهای تفاضلی درجه دوم در فضاهای l^p را تعریف می کنیم و ثابت می کنیم که دقیقا یک تابع درجه دوم k و یک ثابت c وجود دارد،و در نهایت ثابت میکنیم که این عملگرها خطی، پیوسته و وارون پذیر است. فرض کنید e یک فضای باناخ و (x,+,m,m)یک نیم گروه کامل و عینا مساوی با صفر نیست و اندازه x متنا...
Congenital long QT syndrome is a rare disease in which the electrocardiogram QT interval is prolonged due to dysfunctional ventricular repolarization. Variant 3 (LQT-3) is associated with mutations in SCN5A, the gene coding for the heart Na(+) channel alpha subunit. Arrhythmias in LQT-3 mutation carriers are more likely to occur at rest, when heart rate is slow. Several LQT-3 Na(+) channel muta...
BACKGROUND Genetic long QT (LQT) syndrome is a life-threatening disorder caused by mutations that result in prolongation of cardiac repolarization. Recent work has demonstrated that a zebrafish model of LQT syndrome faithfully recapitulates several features of human disease, including prolongation of ventricular action potential duration, spontaneous early afterdepolarizations, and 2:1 atrioven...
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