Radium-223 ((223)Ra) dichloride is an approved intravenous radiotherapy for patients with osseous metastases from castration-resistant prostate cancer (CRPC). In addition to the therapeutic alpha radiation, there is additional (223)Ra radiation generated which produces photons that can be imaged with conventional gamma cameras. No studies have evaluated real-time and quality imaging during intr...

Several studies have identified miR-223 critically involved in various types of cancer, including pancreatic ductal adenocarcinoma (PDAC). However, its action and regulatory mechanisms in PDAC remains largely unclear. In this study, we found that the expression levels of miR-223 were increased in clinical samples with PDAC (81.6%). The upregulation of miR-223 increases the proliferation, migrat...

Lung cancer is the leading cause of cancer-related fatalities worldwide, and non-small cell lung cancer (NSCLC) is the main pathological type. MicroRNAs (miRNAs or miRs) are a class of small non-coding RNAs, which are involved in tumor initiation and progression. miR‑223 is a tumor suppressor miRNA that has been reported in various types of cancer, including lung cancer. In the present study, t...

BACKGROUND Myelosuppression is common in patients with progressive castration-resistant prostate cancer and bone metastases. Radium-223 prolongs overall survival in these patients but may cause myelosuppression; understanding risk factors will improve clinical decision making. We describe hematologic safety of radium-223 in ALSYMPCA and post hoc analyses identifying patients at increased risk f...

There is growing evidence that microRNAs are implicated in pulmonary arterial hypertension (PAH), but underlying mechanisms remain elusive. Here, we identified that miR-223 was significantly downregulated in chronically hypoxic mouse and rat lungs, as well as in pulmonary artery and pulmonary artery smooth muscle cells (PASMC) exposed to hypoxia. Knockdown of miR-223 increased PASMC proliferati...

Question 1. • We studied three types of logging strategies in class: physical, logical, and physiological. Briefly (1-2 lines) explain the difference between the three logging strategies. • Consider recovery algorithms for transaction aborts and system restart that are based on logging. These recovery algorithms require that log records for a transaction must be forced to disk when a transactio...

The human sense of shape and pattern recognition can discern subtle nuances among groups of visual cues that no computer system can reproduce faithfully. Yet when it comes to measuring and evaluating chromatograms, analysts put a great deal of faith into their computerized data-handling systems. During the course of one year, a practising chromatographer might look at 10 000 or more peaks. Afte...

Pulmonary sparganosis mansoni is uncommon in general clinical practice, but prevalent in endemic foci. Pulmonary sparganosis mansoni shares some clinical and radiologic similarities that mimic other common pulmonary pathogens. Delayed diagnosis of pulmonary sparganosis mansoni can pose a significant hazard to the patient. Indeed, a history of ingesting uncooked stone cracks in endemic areas is ...

Currently, there are difficulties associated with the culturing of pluripotent human embryonic stem cells (hESCs), and knowledge regarding their regulatory mechanisms is limited. MicroRNAs (miRNAs) regulate gene expression and have critical functions in stem cell self-renewal and differentiation. Moreover, fibroblast growth factor (FGF) and the insulin-like growth factor receptor (IGF-1R) are k...

BACKGROUND Kawasaki disease (KD) is now the most common cause of acquired cardiac disease in children due to permanent coronary artery damage with unknown etiology. The study sought to determine the role of blood microRNA miR-223 in KD and KD-induced injuries in vascular endothelial cells (ECs) as well as the mechanisms involved. METHODS AND RESULTS MicroRNA profiles in serum from patients wi...