The nonantibiotic small molecule cyslabdan, a labdan-type diterpene produced by Streptomyces sp. K04-0144, markedly potentiated the activity of the β-lactam drug imipenem against methicillin-resistant Staphylococcus aureus (MRSA). To study the mechanism of action of cyslabdan, the proteins that bind to cyslabdan were investigated in an MRSA lysate, which led to the identification of FemA, which...

A problem exists in that the classifications used by the Federal Emergency Management Agency ~FEMA! for weather-related disasters do not always allow analysts to clearly link declared disasters to their ultimate meteorological cause. This research focuses on those disasters related to flooding resulting from tropical cyclones. Neither FEMA nor the states that request federal disaster aid distin...

Why do voters often reward incumbents when they receive government spending? We develop a model in which distributive spending provides voters not just with a financial benefit, but also an opportunity to observe and judge the appropriateness of government decisions. Empirically, we test the model’s predictions using individuallevel data on FEMA disaster relief matched to voter turnout records,...

Of all natural disasters, flooding causes the greatest amount of economic and social damage. The United States' Federal Emergency Management Agency (FEMA) uses a number of hazard mitigation grant programmes for flood victims, including mitigation offers to relocate permanently repetitive flood loss victims. This study examines factors that help to explain the degree of difficulty repetitive flo...

When investigating the potential for xanthine oxidase (XO)-mediated metabolism of a new chemical entity in vitro, selective chemical inhibition experiments are typically used. Most commonly, these inhibition experiments are performed using the inhibitor allopurinol (AP) and commercially prepared human liver cytosol (HLC) as the enzyme source. For reasons detailed herein, it is also a common pra...

In 2001, the Federal Emergency Management Agency (FEMA) required every Florida county to identify potential locations of disaster recovery centers (DRCs). The DRCs are to be opened and staffed by FEMA personnel, subsequent to any declared disaster. The Emergency Management Division of the Alachua County Department of Fire/Rescue Services sponsored a project to identify potential DRC sites. The ...

n 1958, Congress enacted the Food Additives Amendment (FAA) to the Federal Food, Drug, and Cosmetics Act amid growing concern over the safety of substances added to foods. The FAA set forth standards and guidelines by which the safety of food additives must be established before they can be added to foods (FAA, 1958). The FAA contained an exclusion provided by Congress for substances “generally...