The formation of tryptophan (Reactions 1 and 2) requires the coenzyme pyridoxal phosphate. According to the proposed mechanism of action of pyridoxal enzymes (3, 4), the aldolyticl activity of tryptophan synthetase (Reactions 3f and 3r) would not be expected to require pyridoxal-P as a coenzyme; yet DeMoss and Bonner (7) reported that the Reaction 3f activity of a mutationally altered tryptopha...

B> BCOTTHELLtt University president Martin Meyerson is in the process of sec iring a speaker for spring commencement, though there is no word as to whether plans have been finalized, According to Senior Class President Myles Berkowitz, Meyerson"s suggestion for commencement speaker was brought before the University Council committee established to approve the speaker in the wake ol lail >cat's ...

Cancer cells decorate their surface with a dense layer of sialylated glycans by upregulating the expression of sialyltransferases and other glycogenes. Although sialic acids play a vital role in many biologic processes, hypersialylation in particular has been shown to contribute to cancer cell progression and metastasis. Accordingly, selective strategies to interfere with sialic acid synthesis ...

Fmoc-3F-Phe-Arg-NH2 and Fmoc-3F-Phe-Asp-OH dipeptides undergo coassembly to form two-component nanofibril hydrogels. These hydrogels support the viability and growth of NIH 3T3 fibroblast cells. The supramolecular display of Arg and Asp at the nanofibril surface effectively mimics the integrin-binding RGD peptide of fibronectin, without covalent connection between the Arg and Asp functionality.

Peroxisome proliferator-activated receptor γ (PPARγ) is recognized as a key regulator of insulin resistance. In this study, we searched for novel PPARγ agonists in a library of structurally diverse organic compounds and determined that podophyllotoxin exhibits partial agonist activity toward PPARγ. Eight novel podophyllotoxin-like derivatives were synthesized and assayed for toxicity and functi...

A novel class of asymmetric mono-carbonyl analogs of curcumin (AMACs) were synthesized and screened for anti-inflammatory activity. These analogs are chemically stable as characterized by UV absorption spectra. In vitro, compounds 3f, 3m, 4b, and 4d markedly inhibited lipopolysaccharide (LPS)-induced expression of pro-inflammatory cytokines tumor necrosis factor-α and interleukin-6 in a dose-de...

Semaphorins 3A and 3F are axon guidance proteins during nervous system development. Their expression pattern and function outside the nervous system are unknown. Neuropilin 1 and 2 (NP-1, NP-2) are natural ligands for semaphorins 3A and 3F, respectively. NP-1 is also a co-receptor for vascular endothelial growth factor (VEGF) required for normal vascular development. We showed that VEGF is a di...

در بررسی­های فونستیک سال 2011 دامنه جنوبی رشته کوه­های زاگرس ایران، یک نمونه ماده از گونه Amphipyra kautti Hacker, 2002 متعلق به خانواده Noctuidae و زیرخانواده Amphipyrinae مناطق کوهستانی استان کهگیلویه بویراحمد جمع­ آوری شناسایی شد. این که برای اولین بار ایران گزارش می­شود، همراه با ویژگی­های افتراقی، تصویر الگوی بال اندام تناسلی شده ارائه است. اطلاعات مربوط دیگر همین جنس مطالعه نیز

The combination of specific mechanical, esthetic, and chemical properties is decisive for the application of materials in prosthodontics. Controlled twofold crystallization provides a powerful tool to produce special property combinations for glass-ceramic materials. The present study outlines the potential of precipitating Ca5(PO4)3F as well as Sr5(PO4)3F as minor crystal phases in Li2Si2O5 gl...

Sutureless aortic bioprosthesis implantation is an alternative technique in high-risk patients undergoing aortic valve replacement with a possible reduction in the extracorporeal circuit time and reliable haemodynamic features. A 3F Enable (ATS Medical-Medtronic, Inc., Minneapolis, MN, USA) has shown very good results. We report the first upward displacement of 3F Enable three months post impla...