Actinonin, an antibiotic and CD13/aminopeptidase N (APN) inhibitor, has been shown to be cytotoxic to tumor cell lines in vitro. We investigated the antiproliferative effects of actinonin on human and murine leukemia and lymphoma cells. Actinonin inhibited growth of NB4 and HL60 human cell lines and AKR mouse leukemia cells in vitro with an IC50 of about 2-5 micrograms/ml. The inhibitory effect...

We present a proof of the existence and uniqueness theorem of a normalizing biholomorphic mapping to Chern-Moser normal form. The explicit form of the equation of a chain on a real hyperquadric is obtained. There exists a family of normal forms of real hypersurfaces including Chern-Moser normal form. 0. Introduction Let M be an analytic real hypersurface with nondegenerate Levi form in a comple...

A human acute myeloid leukemia model has been developed by i.v. transplantation of HL-60 myeloid leukemia cells into Swiss nude mice pretreated with cyclophosphamide. HL-60 cells disseminated into hematopoietic tissues as determined by flow cytometric analysis, fluorescence microscopy, fluorescence in situ hybridization analysis, and colony formation assay. Passive immunotherapy using murine an...

We investigated the effect of high fat and nutrient depleted diets on the formation of colon tumors in female Swiss mice treated with 1,2-dimethylhydrazine (DMH). Mice received the following diets: control diet (laboratory chow, 5.5% fat) or chow with added starch and/or corn oil so as to supply a fat level of 5.5% (diet F6) or 23% (diet F23), while reducing the level of nutrients and dietary f...

We focus on investor-state dispute settlement provisions contained in various, though far from all, bilateral investment treaties as a possible determinant of BIT-related effects on bilateral FDI flows. Our estimation results prove to be sensitive to the specification of these provisions as well as the inclusion of transition countries in the sample. Stricter dispute settlement provisions do no...

The PaPer examines the shifts in attitudes to foreign investment; charts the dimensions and composition of capital flows to develeping countries; outlines existing barriers and the effects of taxation on these flows, and critically examines the demand for their regulation in the light of the Asian crisis. JEL classification: F3, F21, F23 Address: Dept. of Economics, UCLA, 405 Hilgard Avenue, Lo...

In this paper, we analyze tax competition in a model where investor firms have the choice between two types of investment, greenfield investment and mergers and acquisitions. We show that the coexistence of these two types of investment intensifies tax competition in comparison to the case where there is only greenfield investment. If a specific tax on acquisitions is available, this result cha...

MARKET STRUCTURE, TRADE LIBERALIZATION AND THE GATS J.F. Francois and I. Wooton Abstract: In this paper we consider the impact of improved domestic market access for a foreign service provider. We emphasize the interaction between the different modes of market access commitments in services (cross-border and establishment) market structure, and regulation. We work with a model where the domesti...