The mitochondrial permeability transition (mPT) involves the opening of a non-specific pore in the inner membrane of mitochondria, converting them from organelles whose production of ATP sustains the cell, to instruments of death. Here, I first summarize the evidence in favour of our model for the molecular mechanism of the mPT. It is proposed that the adenine nucleotide translocase (ANT) is co...

BACKGROUND Miriplatin (MPT) is a novel platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC). However, rapid washout has been reported in some cases. Therefore, various methods of administration with MPT have been attempted to increase its therapeutic efficacy. One hopeful method is balloon-occluded TACE (B-TACE), but the therapeutic efficacy of B-...

Methods have been devised to examine the spectral properties and state of reduction of the pterin ring of molybdopterin (MPT) in milk xanthine oxidase and the Mo-containing domain of rat liver sulfite oxidase. The absorption spectrum of the native pterin was visualized by difference spectroscopy of each protein, denatured anaerobically in 6 M guanidine hydrochloride (GdnHCl), versus a sample co...

The molybdenum cofactor (Moco), a highly conserved pterin compound coordinating molybdenum (Mo), is required for the enzymatic activities of molybdoenzymes. In all organisms studied so far Moco is synthesized by a unique and evolutionary old multistep pathway that requires the activities of at least six gene products. In eukaryotes, the last step of Moco synthesis, i.e., transfer and insertion ...

| EEcient support for scalable multipoint-to-multipoint (mpt-mpt) communication in ATM has recently become a hot topic of discussion at the ATM Forum. In our previous study 11], we presented a new class of eecient switch algorithms for point-to-multipoint (pt-mpt) ABR service that deliver high performance in terms of fairness and link utilization and are signiicantly simpler to implement than o...

The mitochondrial permeability transition (MPT) plays an important role in hepatocyte death caused by ischemia-reperfusion (IR). This study investigated whether activation of the cellular oxygen-sensing signal cascade by prolyl hydroxylase inhibitors (PHI) protects against the MPT after hepatic IR. Ethyl 3,4-dihyroxybenzoate (EDHB, 100 mg/kg ip), a PHI, increased mouse hepatic hypoxia-inducible...

هدف: کبد از حساس‌ترین بافت‌های هدف فشار اکسایشی ناشی تمرین می‌باشد و آمینوترانسفراز‌های کبدی، شاخص‌های حساسی برای تعیین آسیب دیدگی سلول‌های کبدی هستند. پژوهش حاضر با مقایسه تأثیر هشت هفته TRX مقاومتی سنتی بر برخی آنزیم‌های (آسپارتات آمینو ترانسفراز آلانین ترانسفراز) در زنان غیرفعال انجام گرفت.روش ­ها: این که به روش نیمه تجربی شد، 28 دختر میانگین سن41/1±07/21 سال شاخص توده بدن 25/4±52/22 کیلوگرم...

زمینه و هدف: microRNA (miRNA) دستة جدیدی از شاخص‌های زیستی‌اند که در سطح سلولی مسیرهای پیام‌رسانی تغییرات ساختاری عملکردی قلبی درگیرند. همچنین تمرینات تناوبی شدید (HIIT) شامل وهله‌های فعالیت ورزشی نسبتاً با مدت زمان کوتاه است دوره‌های بازیافت فعال یا غیرفعال یکدیگر جدا شده‌اند، می‌تواند سبب بهبود آمادگی قلبی-تنفسی متغیرهای فیزیولوژیک متناظر آن افراد سالم شود. ازاین‌رو پژوهش حاضر نظر دارد اثر هشت...