Hyperpolarization-activated, cyclic nucleotide-gated, nonspecific cation (HCN) channels have a well-characterized role in regulation of cellular excitability and network activity. The role of these channels in control of epileptiform discharges is less thoroughly understood. This is especially pertinent given the altered HCN channel expression in epilepsy. We hypothesized that inhibition of HCN...

It is widely accepted that the induction dose of anesthetics is higher in infants than in adults, although the relevant molecular mechanism remains elusive. We previously showed neuronal hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels contribute to hypnotic actions of propofol and ketamine. Interestingly, the expression of HCN channels in neocortex significantly changes duri...

HCN cation channel mRNA expression was determined in the rabbit heart and neonatal and adult rat ventricle using RNase protection assays. In the rabbit SA node, the dominant HCN transcript is HCN4, representing >81% of the total HCN message. HCN1 is also expressed, representing >18% of the total HCN mRNA. Rabbit Purkinje fibers contained almost equal amounts of HCN1 and HCN4 transcripts with lo...

We present radio-interferometric observations of HCN J = 1 → 0 line emission from the carbon star R Scl, obtained with the interim 3-mm receivers of the Australia Telescope Compact Array. The emission is resolved into a central source with a Gaussian FWHM of ∼1 ′′ , which we identify as the present mass loss envelope. Using a simple photodissociation model and constraints from single-dish HCN s...

We present new HCN and HCO + ( J = 3–2) images of the nearby star-forming galaxies (SFGs) NGC 3351, 3627, 4321. The observations, obtained with Morita ALMA Compact Array, have a spatial resolution ∼290–440 pc resolve inner R gal ≲ 0.6–1 kpc targets, as well southern bar end 3627. complement this data set publicly available lower excitation lines HCN, , CO analyse behaviour representative line r...

A growing body of research suggests that impaired bladder Cajal-like interstitial cells (ICCs) are a important component in the pathogenesis of diabetes-induced bladder dysfunction, although the molecular mechanisms have not been illustrated completely. The purpose of this study was to examine whether the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in ICCs-DM were respons...

In this research, the interactions of HCN gas with pristine, Ga-, N- and GaN-doped of boron phosphide nanotube (BPNTs) were investigated by using density function theory (DFT). The structure, electrical and NQR parameters, quantum descriptors involving energy gap, global hardness, global softness, electrophilicity, electronic chemical potential and electronegativity were calculated. The adsorpt...

Monte Carlo simulations were employed to gain insight on HCN adsorption mechanism on LTA zeolites with different alkali metal cations, Li, Na, and K. Adsorption isotherms were calculated at four different temperatures at and above the normal boiling point of HCN. Results show that adsorption capacity depends on the type of the extraframework cation and Li-LTA showed the highest HCN adsorption c...

Hollow graphitic carbon nitride (HCN) ZrO2/g-C3N4 hybrid composites (HCN–ZR) and the target catalyst Fe/ZrO2/g-C3N4 (HCN–FZR) were prepared successfully by a solvo-thermal method and evaluated for photo-degradation of organic pollutants, i.e. MO, and herbicides, metsulfuron methyl (MTSM). These materials were characterized by a variety of techniques, including Fourier transform infrared spectro...