A typical B-rep describes a solid in its full detail. Operations that locally analyze the B-rep usually process the entire B-rep due to the lack of spatial ordering of its topological entities. For very complex objects, this global processing is time consuming and yet unnecessary. One approach in avoiding the global processing is to use several B-reps of different levels of detail. However, thi...

The seismic response characteristics of a lead-rubber-bearing(LRB) base-isolated structure under rare and very earthquakes were investigated. acceleration, ductility coefficient, shear strain the LRB increase significantly in comparison to earthquakes; particular, may exceed ultimate cause damage structure. criterion selected for optimum tuned inerter damper (TID) TID–LRB hybrid control system ...

Bardet-Biedl syndrome (BBS) is a highly pleiotropic autosomal recessive disorder associated with a wide range of phenotypes including obesity. However, the underlying mechanism remains unclear. Here, we show that neuronal BBSome is a critical determinant of energy balance through its role in the regulation of the trafficking of the long signaling form of the leptin receptor (LRb). Targeted disr...

Lithol Rubine B (LRB; the disodium salt of 3-hydroxy-4-[(4-methyl-2-sulfophenyl) azo]-2-naphthalenecarboxylic acid) was detected using high-performance liquid chromatography with an electrochemical (antimony film on silver) detector (HPLC-ECD). For direct current (DC) mode, with the current at a constant potential, and measurements with suitable experimental parameters, a linear concentration f...

Vegetation plays a very important role of carbon (C) sinks in the global C cycle. With its complex terrain and diverse vegetation types, the Lancang River Basin (LRB) of southwest China has huge C storage capacity. Therefore, understanding the spatial variations and controlling mechanisms of vegetation C storage is important to understand the regional C cycle. In this study, data from a forest ...

Most G protein-coupled receptors (GPCRs) do not generate membrane currents in response to ligand-receptor binding (LRB). Here, we describe a novel technique using endocytosis as a bioassay that can detect activation of a GPCR in a way analogous to patch-clamp recording of an ion channel in a living cell. The confocal imaging technique, termed FM endocytosis imaging (FEI), can record ligand-GPCR...

The NTP lifetime rodent bioassay (LRB) is the "gold standard" for predicting human carcinogenicity. Unfortunately, little attempt has been made to validate it against human carcinogenicity. Here we show that the extremely limited data available do not support either of the two common interpretations of LRB results. If a risk-avoidance interpretation is used where any positive result in a sex/sp...

This comment examines the Legal framework of collective labour disputes (CLD) resolution by Labour Relation Board (LRB) in Ethiopia. Only two members LRB out seven (and alternate members) are from legal profession. Moreover, there is no provision (under Proclamation) regarding selection criteria other Board. The decision rendered majority vote and appeal permitted only on error relating to issu...

This study presents a novel self-centering (SC) base isolation system enabled by traditional lead rubber bearing (LRB) incorporating superelastic shape memory alloy (SMA) U-shaped dampers (hereinafter referred to as SMA-LRB). is particularly suitable for some important structures (e.g., hospital buildings) that require high seismic performance and rapid recovery of normal serviceability after s...