Based on current studies on the effects of single dose vaccines on antibody production, Latin American countries have adopted a single dose vaccine program. However, no data are available on the activation of cellular response to a single dose of hepatitis A. Our study investigated the functional reactivity of the memory cell phenotype after hepatitis A virus (HAV) stimulation through administr...

Purpureocillium lilacinum is a filamentous, hyaline fungus considered an emerging pathogen in humans. The aim of our study was to evaluate the outcome of hyalohyphomycosis in C57BL/6 murine models inoculated with two clinical P. lilacinum isolates (S1 and S2). Each isolate was inoculated in mice randomly distributed in immunocompetent (CPT) and immunosuppressed (SPS) groups. Mice were evaluated...

O vírus da Imunodeficiência Humana (HIV) infecta predominantemente as células TCD4+, e a destruição dessas pode ocorrer pelo efeito citopático do vírus. Adicionalmente, existe um aumento apoptose e, por expressarem antígenos virais no nível membrana, podem também ser destruídas citotoxicidade mediada pela célula TCD8+, fenômeno que contribui para redução das CD4+. Tem como objetivo esclarecer c...

A variety of mechanisms are involved in the regulation of offspring allergy development through maternal immunization with allergens. The passive transfer of antigens, antibodies, and cytokines, the induction of phenotypic alterations in offspring lymphocytes, and the induction of regulatory populations in offspring have been proposed, but these mechanisms remain incompletely understood. It is ...

Mục tiêu: Bước đầu khảo sát sự thay đổi tế bào lympho T và dưới nhóm, B diệt tự nhiên (Natural Killer – NK) máu ngoại vi trong viêm phổi ở trẻ em. Đối tượng phương pháp: Nghiên cứu mô tả cắt ngang trên 192 bệnh nhân từ 0 60 tháng tuổi tại Bệnh viện Nhi Trung ương. Các NK được xác định bằng kỹ thuật đếm dòng chảy máy FACS Canto-II sử dụng bộ Kit BD Multitest 6 color TBNK. Kết quả: Tỷ lệ các có g...

Central neuropathic pain (CNP) is considered as a complicated sensory disturbance which many multiple sclerosis (MS) patients suffer from. Although monophasic experimental autoimmune encephalomyelitis (EAE) mouse model is a gold standard model in preclinical research of MS, severe movement deficit could confound pain behaviors evaluation over the disease course. In this study, complete Freund&r...

T lymphocytes that are involved in cellular mediated immunity include two types known as TCD8+ (Cytotoxic T lymphocytes) and TCD4+ (helper T lymphocytes). TCD4+ has four main subtypes, including TH1, TH2, TH17, and Treg Lymphocytes.TH17 lymphocytes play a role in defense against microbes that TH1 and TH2 lymphocytes have not the ability to respond to them. The most important cytokines, which ar...