Pulmonary artery endothelial cells (PAEC) isolated from fetal lambs with in utero pulmonary hypertension (IPH) have phenotypical changes that lead to increased reactive oxygen species (ROS) formation and impaired angiogenesis. AMP-activated protein kinase (AMPK) is known to be activated by ROS, which is expected to help angiogenesis in IPH-PAEC. The objectives of this study were to investigate ...

OBJECTIVE Isolated postchallenge hyperglycemia (IPH), defined as fasting plasma glucose (FPG) level <7.0 mmol/l and 2-h plasma glucose (PG) level >/=11.1 mmol/l, is a subtype of early-stage diabetes. This study evaluates the metabolic profiles of insulin secretion and insulin sensitivity in IPH to clarify the factors responsible for development of this form of type 2 diabetes. RESEARCH DESIGN...

We report a case of idiopathic portal hypertension (IPH) in association with autoimmune thyroiditis occurring in a 39 year old woman. Ultrasonography revealed a normal liver echotexture. Spleno-portogram confirmed portal hypertension and liver biopsy showed features in keeping with IPH. She was also found to be biochemically hypothyroid with markedly elevated thyroid autoantibodies. These findi...

In our previous study in guinea pigs, intensive and prolonged intraperitoneal heating (IPH) caused heat stroke characterized by high mortality and accompanied by two paradoxical phenomena: ear skin vasoconstriction at a high body temperature (Tb) (hyperthermia-induced vasoconstriction) and a post-IPH Tb fall at an ambient temperature (Ta) below thermoneutrality (hyperthermia-induced hypothermia...

PURPOSE To determine if complicated plaque can be found by using magnetic resonance (MR) imaging-depicted intraplaque hemorrhage (IPH), even among symptomatic patients with low-grade (≤50%) carotid stenosis. MATERIALS AND METHODS The institutional ethics review board approved this retrospective study and waived requirements for written informed consent. Symptomatic patients with bilateral 0%-...

Introduction: Intraplaque hemorrhage (IPH) into the carotid atherosclerotic plaque has shown significant association with clinical symptoms and is believed to be a major factor causing plaque instability and progression according to previous histopathological and prospective studies . With the development of magnetic resonance imaging (MRI) in clinical diagnostics, several techniques have been ...

Atherosclerosis in the carotid arteries is an important cause of ischemic stroke. Treatment decisions for carotid artery stenosis are currently based on the degree of luminal narrowing and the presence or absence of recent ipsilateral stroke or transient ischemic attack (TIA). However, there is increasing evidence that additional factors may be useful in stratifying a patient’s risk of stroke r...

PURPOSE To evaluate the efficacy of intracameral phenylephrine (IPH) administered as prophylaxis against intraoperative floppy iris syndrome (IFIS) and to analyze the ability of IPH to reverse IFIS. DESIGN Prospective, multicenter, randomized, comparative case series of fellow eyes. PARTICIPANTS Forty-two patients receiving tamsulosin who underwent cataract surgery between January and April...

BackgroundCOL4A1/A2 variants affecting the alpha 1 and 2 chains of type IV collagen are increasingly recognized as a cause fetal neonatal intracranial hemorrhage, porencephaly, schizencephaly. Fetal magnetic resonance imaging (MRI) findings in COL4A1/A2-related disorders not well characterized.MethodsThis is retrospective case series MRI eight patients with intraparenchymal hemorrhage (IPH) COL...