In the 1980’s, isolated case reports appeared in the world literature documenting patients who appeared to suffer from an often fatal complication associated with the demonstration of antiphospholipid antibodies (aPL). The clinical picture comprised widespread multi-organ thrombosis and consequent organ failure and was referred to by the authors as a “devastating non-inflammatory vasculopathy”,...

Background: The anti-inflammatory cytokine, interleukin 10 (IL 10), has a crucial role in periodontal diseases. gene coding for this cytokine is pleomorphic. In the promoter region of IL gene, two single nucleotide polymorphisms (SNPs), IL10 1082 and 819, have been discovered to affect expressions. Objective: To investigate association (IL-10-1082 G/A IL-10-819 C/T) with CPO. Patients Methods: ...

background: gastric cancer (gc) is one of the most commonly diagnosed malignancies. genetic variation in genes encoding cytokines and their receptors, determine the intensity of the inflammatory response, which may contribute to individual differences in the outcome and severity of the disease. interleukin-10 (il-10) is a multifunctional cytokine with both immunosuppressive and antiangiogenic f...

Background: IL-10 is an anti-inflammatory cytokine which is involved in tumorigenesis. Over production of IL-10 and elevated number of IL-10 generating mononuclear cells in breast tumor tissue has already been shown. Objective: To determine the association of IL-10 promoter polymorphisms with increased risk of breast cancer and its association with breast cancer prognostic factors. Methods: Per...

immune responses play critical roles in the leishmaniasis eradication. il-10 is a key regulator of immune responses, and the polymorphisms within its promoter region are associated with alteration in its expression. therefore, this study was designed to examine the correlation between polymorphism at the -1082 position of the il-10 gene and visceral leishmaniasis (vl).the il-10 -1082 polymorphi...

OBJECTIVE Previous studies have evaluated the associations of TNF-α, IL-10 gene polymorphisms and susceptibility to pSS, but the results remained controversial. To assess the associations between TNF-α-308, IL-10-1082, -819, -592 polymorphisms and pSS risk, a meta-analysis was conducted. METHOD The available articles were searched in PubMed, EMBASE and MEDLINE. ORs with 95% CIs were calculate...

BACKGROUND Interleukin-10 (IL-10) is a multifunctional regulatory cytokine that might be associated with increased risk of type 2 diabetes mellitus (T2DM). IL-10 gene polymorphisms have been reported to be associated with T2DM in several ethnic populations with controversial results. OBJECTIVES This work is an updated meta-analysis aiming at the evaluation of the association between IL-10 gen...