CONTEXT Gastroesophageal reflux disease (GERD) is a chronic, relapsing disease with symptoms that have negative effects on daily life. Two treatment options are long-term medication or surgery. OBJECTIVE To evaluate optimized esomeprazole therapy vs standardized laparoscopic antireflux surgery (LARS) in patients with GERD. DESIGN, SETTING, AND PARTICIPANTS The LOTUS trial, a 5-year explorat...

Several aminoacyl-tRNA synthetases have been reported to be overexpressed for charging essential aminoacyl-tRNAs in many cancer types. In this study, we aimed to explore the potential role of leucyl-tRNA synthetase (LARS) as an anticancer target. MTT assay was performed to screen inhibitors to human LARS (hsLARS) from compounds AN2690 and its derivatives, compounds 1-6, in U2OS and SKOV3 cells....

This paper proposes LARS*, a location-aware recommender system that uses location-based ratings to produce recommendations. Traditional recommender systems do not consider spatial properties of users nor items; LARS*, on the other hand, supports a taxonomy of three novel classes of location-based ratings, namely, spatial ratings for non-spatial items, non-spatial ratings for spatial items, and ...

On Tuesday 28 June 2011, Lars Haaheim tragically died whilst on a fishing trip in a fjord near his summer home in Sveio, Norway. Lars was an internationally renowned influenza scientist and a founder member of the International Society for Influenza and Other Respiratory Viruses (isirv). From his formative academic years at the University of Bergen, Lars was an influenza enthusiast. He speciali...

The American Cancer Society estimated that 39,610 new cases of rectal cancer were diagnosed in the United States in 2015. Surgery is the primary treatment for rectal cancer, with the majority of patients undergoing sphincter-preserving surgery with low anterior resection. Although low anterior resection can prevent patients from having a permanent colostomy, bowel dysfunction may occur in 60% t...

As ever-larger knowledge bases (KBs) are being built, knowledge sharing becomes an aspect of paramount importance in Knowledge Base Management Systems (KBMSs). In this paper, we propose a way of controlling knowledge sharing by means of the LARS (Locks using Abstraction Relationships’ Semantics) approach for concurrency control in KBs. LARS synchronizes transactions through many different granu...