This study examined whether cardiocyte load increases eIF-4F complex formation. To increase load in vitro, adult feline cardiocytes were electrically stimulated to contract (1 Hz, 5-ms pulses). eIF-4F complex formation, measured by eIF-4G association with eIF-4E, increased 57 ± 16% after 4 h of contraction compared with controls. eIF-4F complex formation did not increase on electrical stimulati...

Background—These studies were designed to determine the mechanism of action of an oral apolipoprotein (apo) A-I mimetic peptide, D-4F, which previously was shown to dramatically reduce atherosclerosis in mice. Methods and Results—Twenty minutes after 500 g of D-4F was given orally to apoE-null mice, small cholesterolcontaining particles (CCPs) of 7 to 8 nm with premobility and enriched in apoA-...

The ability of polypeptide components of eukaryotic initiation factor (eIF) 4F to bind to the m7G cap of an mRNA, to be released from that mRNA, and then to rebind to the cap of a second mRNA has been investigated. The release and rebinding steps have been termed "recycling." It was found that eIF-4B stimulates the recycling of the 24-26 kDa (p24) component of eIF-4F, and perhaps of other compo...

BACKGROUND Rapid reversal of vitamin K antagonist (VKA)-induced anticoagulation is often necessary for patients needing urgent surgical or invasive procedures. The optimum means of VKA reversal has not been established in comparative clinical trials. We compared the efficacy and safety of four-factor prothrombin complex concentrate (4F-PCC) with that of plasma in VKA-treated patients needing ur...

We preseut a model for the calculation of the static magnetic susceptibility m samarium sulphide type semicouductiug compouuds. Trie bd stores are schematically treated, as well as trie forbidden gap, accordiug to a realistic bond scheme for SmS, whereas two iouic configurations 4f~ and 4f° in their fundamental multiplets are considered: 4f°

BACKGROUND Hypercholesterolemia and sickle cell disease (SCD) impair endothelium-dependent vasodilation by dissimilar mechanisms. Hypercholesterolemia impairs vasodilation by a low-density lipoprotein (LDL)-dependent mechanism. SCD has been characterized as a chronic state of inflammation in which xanthine oxidase (XO) from ischemic tissues increases vascular superoxide anion (O2*-) generation....

BACKGROUND We recently developed a 4F child catheter that can be inserted into 6F or larger conventional guiding catheters. The use of 4F mother-child technique may improve the delivery of coronary stents to complex lesions. Accordingly, we sought to determine the potential of using a 4F mother-child technique to treat complex coronary lesions. METHODS AND RESULTS The support power and the tr...

Bulk-sensitive high-resolution Ce 4f spectra have been obtained from 3d→4f resonance photoemission measurements on La1−xCexAl2 and La1−xCexRu2 for x = 0.0, 0.04, 1.0. The 4f spectra of low-Kondo-temperature (TK) (La,Ce)Al2 are essentially identical except for a slight increase of the Kondo peak with x, which is consistent with a known increase of TK with x. In contrast, the 4f spectra of highTK...

RacoonWW is an event generator for ee → WW → 4 fermions(+γ) that includes full tree-level predictions for ee → 4f and ee → 4f + γ as well as O(α) corrections to ee → 4f in the so-called double-pole approximation. We briefly sketch the concept of the calculation on which this generator is based and present some numerical results.

Kidney injury, heart injury, and cytokine-induced vascular hyperpermeability are associated with high rates of morbidity and mortality in sepsis. Although the mechanism remains unknown, apolipoprotein A-I (apoA-I) mimetic peptide 4F reduces inflammation and protects HDL levels, which are reduced in sepsis. We hypothesized that 4F also protects kidneys and hearts in a rat model of cecal ligation...