BACKGROUND It is necessary to develop novel, affordable, and accessible drugs with few side effects as alternatives of the currently available chemical agents for leishmaniasis. OBJECTIVES The main purpose of this study was to evaluate the effects of these drugs on L. major under in vitro conditions. MATERIALS AND METHODS In the current study, 5, 10, 25, 50, and 100 µg/mL concentrations of ...

Artemisinin (quinghaosu) is a natural compound, isolated from Artemisia annua L. (Compositae), of current interest in treatment of drug-resistant malaria. Aim of the current study was to hit upon novel artemisinin sources as alternative to A. annua. Therefore, ten species of the genus Artemisia (A. santonicum L., A. taurica Willd., A. spicigera K. Koch, A. herba-alba Asso, A. haussknechtii Bois...

We report the chemical composition and anti-Leishmania and antioxidant activity of Artemisia campestris L. and Artemisia herba-alba Asso. essential oils (EOs). Our results showed that these extracts exhibit different antioxidant activities according to the used assay. The radical scavenging effects determined by DPPH assay were of IC50 = 3.3 mg/mL and IC50 = 9.1 mg/mL for Artemisia campestris a...

Essential oil from aerial parts of Artemisia vulgaris L., was obtained by hydro-distillation to produce oil in the yield of 0.25% (w/w). The oil was analyzed by capillary gas chromatography, using mass spectrometric detection. The amount of the samples injected by nano scale included were 1.0 nL (diluted 1.0 μL of sample in 1000 ml of n-pentane, v/v). Twenty three bioactive and flavour molecule...

aims: leishmaniasis is the most prevalent vector- borne parasitic disease in iran. drug treatment is the best way to treat leishmaniasis, while the common drugs are not efficient enough and inevitable side effects limit using these drugs. the aim of this study was to analyze in vitro and in vivo activity of the methanolic extract of artemisia absinthium, vitex agnus-castus and phytolaca america...