osteosarcoma (osteogenic sarcoma: os) is the most common primary malignant bone tumor of long bones, whereas primary osteosarcoma of chest wall, especially in sternum, is extremely rare. we report a 57-year-old man with an immobile slow growing mass located in the middle of the sternum. the patient had no significant pain or tenderness and the past medical history was not remarkable. ct-scan sh...

mTOR is a valuable oncotarget for osteosarcoma. The anti-osteosarcoma activity by a novel mTOR kinase inhibitor, CZ415, was evaluated. We demonstrated that CZ415 potently inhibited survival and proliferation of known osteosarcoma cell lines (U2OS, MG-63 and SaOs2), and primary human osteosarcoma cells. Further, CZ415 provoked apoptosis and disrupted cell cycle progression in osteosarcoma cells....

Abstract: Aim/Background: Osteosarcoma is one of the prevalent cancers occurring mostly in adolescents and has a high risk malignancy. With complications involved current treatment strategies, alternates including use phytochemicals have gained fame. Cranberries are known for their exceptional health benefits been explored effective activities various cancers. The study aimed at evaluating anti...

Osteosarcoma is the most common primary bone tumor in children and teens. The exact molecular mechanism underlying osteosarcoma progression still remains unclear. The CX3CL1/fractalkine has been implicated in various tumors but not in osteosarcoma. This study is the first to show that fractalkine promotes osteosarcoma metastasis by promoting cell migration. Fractalkine expression was higher in ...

Osteosarcoma is a primary malignant bone tumor that has a poor prognosis due to local recurrence, metastasis, and chemotherapy resistance. Therefore, there is an urgent need to develop novel potential therapeutic targets for osteosarcoma. Enhancer of zeste homologue 2 (EZH2) is a member of the polycomb group of proteins, which has important functions in epigenetic silencing and cell cycle regul...

MiR-429 functions as a tumor suppressor and has been observed in multiple types of cancer, but the effects and mechanisms of miR-429 in osteosarcoma are poorly understood. This study is performed to evaluate the functions of miR-429 in the progression of osteosarcoma. Firstly, the miR-429 expression in osteosarcoma tissues and osteosarcoma cells was detected using real time PCR, and the relatio...

background: osteosarcoma is a malignant tumor with high mortality but effective therapy has not yet been developed. berberine, an isoquinoline alkaloid component in several chinese herbs including huanglian, has been shown to induce growth inhibition and the apoptosis of certain cancer cells. the aim of this study was to determine the role of berberine on human osteosarcoma cell lines u2os and ...

Osteosarcoma is a malignant tumor with mesenchymal origin, most commonly found in extremities, pelvis and axial skeleton, including only 6% mandibular maxillary involvement. In jaws, this lesion is, generally, single predilection for posterior ramus mandible men the third or fouth decade of life. The aim study report 57year old woman diagnosed osteosarcoma region treated surgical resection asso...

conversion of knee arthrodesis to total knee arthroplasty is a difficult procedure accompanied by many complications due to soft tissue and extensor mechanism contracture and bone defects. we report two cases of distal femur osteosarcoma that had been undergone wide resection arthrodesis initially. arthrodesis was converted to total knee arthroplasty with hinged prosthesis after many years. we ...

BACKGROUND Osteosarcoma is the most common type of bone cancer and is notorious for its rapid progression. The Notch signaling pathway has recently been shown to be involved in osteosarcoma. As a major sheddase of Notch receptors, ADAM10 has been implicated in many types of cancers, but its role in osteosarcoma has not been investigated. Previous studies have shown that the expression of CD31 w...