23 Background: Early phase clinical trials usually include patients (pts) with advanced disease who have failed to standard therapies. palliative care (EPC) for these pts has shown improve quality of life and even survival. Pallia 10 score (from 1 10) is a tool developed by the French Palliative Care Society identify best time introduce care. Methods: We assessed other prognostic factors (age, ...

ion ICFEM’04, Seattle, 12/Nov/2004 Slide 53 (cs(· · ·), Ψ) abstracts to (cs(· · ·), Φ) where Ψ |= Φ Key Advantage: • In infinite state problems, can make it finite; • In traversing the program flow, can reduce the number of steps to a (post-)fixpoint. Key Problem: how to derermine the abstraction? Many verification systems use the methodology of Counter-example Guided Abstraction Refinement eg ...

The MAGE-C1/CT7 encodes a cancer/testis antigen (CTA), is located on the chromosomal region Xq26-27 and is highly polymorphic in humans. MAGE-C1/CT7 is frequently expressed in multiple myeloma (MM) that may be a potential target for immunotherapy in this still incurable disease. MAGEC1/CT7 expression is restricted to malignant plasma cells and it has been suggested that MAGE-C1/CT7 might play a...

INTRODUCTION Administration of human C1 esterase inhibitor (Berinert(®) P) from target import is the most widespread treatment strategy for patients with hereditary angioedema (HAE). However, a therapeutic health program including Ruconest(®) (conestat alfa) could shorten a patient's expectancy for a life-saving treatment. AIM To evaluate the cost-utility of Ruconest(®) (conestat alfa) financ...

Let M be a compact smooth manifold of holonomy G2. We prove that the space of infinitesimal associative deformations of a compact associative submanifold Y with boundary in a coassociative submanifold X is the solution space of an elliptic problem. Further, we compute its virtual dimension. For ∂Y connected it is given by ∫ ∂Y c1(νX)+ 1− g, where g denotes the genus of ∂Y , νX the orthogonal co...

We show that if G1 and G2 are non-solvable groups, then no C1,τ action of $(G_{1}\times G_{2})*\mathbb {Z}$ on S1 is faithful for τ > 0. As a corollary, S an orientable surface complexity at least three the critical regularity arbitrary finite index subgroup mapping class group Mod(S) with respect to circle most one, thus strengthening result first two authors Baik.

Polynomial Pythagorean hodograph (PH) curves form a remarkable subclass of polynomial parametric curves; they are distinguished by having a polynomial arc length function and rational offsets (parallel curves). Many related references can be found in the article by Farouki and Neff on C1 Hermite interpolation with PH quintics. We extend the C1 Hermite interpolation scheme by taking additional c...