A 65-year-old comatose man with metastatic melanoma developed rapidly cycling breathing, clusters of approximately 10 abdominal excursions within 3 seconds, interspersed by seconds apnea (video 1 and figure), mimicking myoclonus. Introduced Plum Posner1 as a respiratory pattern associated lesions in the low pons or high medulla, cluster breathing can occur without pontomedullary when alkalosis ...

We report a patient with systemic lupus erythematosus (SLE), who had developed metabolic alkalosis during plasmapheresis. The metabolic alkalosis could be promptly corrected by reducing the amount of citrate load. The development of metabolic alkalosis can be explained by the citrate load during plasmapheresis. Careful monitoring of acid base status is mandatory in patients with limited renal f...

Intravenous infusion of hydrochloric acid was used as a safe, effective, and quantitative method for correction of metabolic alkalosis in two patients. The first shows the risks of intravenously administered ammonium chloride, the currently available alternative to hydrochloric acid therapy. The second shows the efficacy of intravenously administered hydrochloric acid. While breathing spontaneo...

We previously found that nitric oxide synthase (NOS) inhibition fully blocked alkalosis-induced relaxation of piglet pulmonary artery and vein rings. In contrast, NOS inhibition alone had no effect on alkalosis-induced pulmonary vasodilation in isolated piglet lungs. This study sought to identify factors contributing to the discordance between isolated and in situ pulmonary vessels. The roles o...

1. Five males were studied on three occasions, after oral administration of CaCO3 (control), NH4Cl (acidosis) and NaHCO3 (alkalosis), in a dose of 0.3 g/kg, taken over a 3 h period at rest. The subjects then exercised on a cycle ergometer for 20 min at 33% maximal oxygen uptake (VO2 max.), followed by 20 min at 66% and at 95% VO2 max. until exhaustion. 2. Endurance at 95% VO2 max. was longest w...

Respiratory alkalosis may be defined as a state of altered physiochemical processes due to the excessive loss of carbon dioxide through overbreathing. Though this condition is usually referred to as the hyperventilation syndrome, respiratory alkalosis would be more accurate terminology as hyperventilation may occur as a necessary physiologic requirement without producing an alkalotic state. Tha...

This is the first case reported of vomiting-induced metabolic alkalosis associated with myoclonus. The report describes an unusual presentation of myoclonus secondary to acid-base disturbance caused by recreational drug-induced vomiting. The severe derangement of hyponatraemia, hypokalaemia, and alkalosis appears to have been reasonably well tolerated due to the gradual onset and relatively lon...

Although hyperventilation is a well-known compensatory mechanism in metabolic acidosis, compensatory hypoventilation has been inconsistent and confroversial in metabolic alkalosis. Six healthy subjects were studied under baseline conditions and during steady-state metabolic acidosis (seven episodes) and alkalosis (14 episodes). Minute ventilation (yE) fell in metabolic alkalosis and rose in met...

Received: Revised: Accepted: September 18, 2014 September 27, 2014 October 15, 2014 In this study, the effect of fermentative disorders such as acid and alkaline indigestion was investigated in buffaloes. Six buffaloes each suffering from acid and alkaline indigestion was chosen and various physiological parameters were compared with six healthy buffaloes Clinical examination was carried out to...