The optimum surface-fitting method for binary images is extended in order to treat gray images, and a new method to extract edges in three-dimensional gray images is proposed. If voxels that have similar values to the voxel of interest (VOI) are distributed like a two-dimensional curved surface, it is thought that there would be a curved surface at the VOI. To apply the fitting method to gray i...

Résumé. Dans cet article, nous introduisons une nouvelle mesure pour qualifier “l’outlier-ness“ de chaque groupe/cluster. Cette mesure, nommée GOF, est intégrée et estimée dans un processus d’apprentissage non supervisé en utilisant les cartes topologiques. Ceci permet d’apprendre la structure des données tout en fournissant un nouveau score (GOF). Ce paramètre est basé sur la densité et quanti...

This paper discusses a recent development in partial least squares (PLS) path modeling, namely goodness-of-fit indices. In order to illustrate the behavior of the goodness-of-fit index (GoF) and the relative goodness-of-fit index (GoFrel), we estimate PLS path models with simulated data, and contrast their values with fit indices commonly used in covariance-based structural equation modeling. T...

The Department of Health and Human Services Framework for Guiding Funding Decisions about Proposed Research Involving Enhanced Potential Pandemic Pathogens (PPPs) contains a series of principles for governing the funding and conduct of gain-of-function (GOF) research resulting in the creation of PPPs. In this article, I address one of these principles, governing the replacement of GOF research ...

Moving objects of interest (MOOIs) in surveillance videos are detected and encapsulated by bounding boxes. Since moving objects are defined by temporal activities through the consecutive video frames, it is necessary to examine a group of frames (GoF) to detect the moving objects. To do that, the traces of moving objects in the GoF are quantified by forming a spatiotemporal gradient map (STGM) ...

Cisplatin is one of the most common chemotherapeutic drugs for non-small cell lung cancer (NSCLC). However, the response rate is limited because of drug resistance. Histone deacetylase inhibitors (HDACis), which can alter DNA accessibility by regulating chromatin structure and inducing apoptosis, exhibit a synergistic action with cisplatin. However, no biomarkers that can predict the efficacy o...

The present opinion article, while dealing with the debated origin of “Severe Acute Respiratory Syndrome-Coronavirus-2” (SARS-CoV-2), betacoronavirus responsible for “Corona Virus Disease-2019” (COVID-19), provides a speculative insight into so-called “gain function” (GOF), process resulting in acquirement new phenotypic features on behalf viral pathogen. More detail, GOF-related phenomenon lea...

Overactivation of receptor tyrosine kinases (RTKs) has been linked to tumorigenesis. To understand how a hyperactivated RTK functions differently from wild-type RTK, we conducted a genome-wide systematic survey for genes that are required for signaling by a gain-of-function mutant Drosophila RTK Torso (Tor). We screened chromosomal deficiencies for suppression of a gain-of-function mutation tor...

To test whether the model fits the data well, a goodness-of-fit (GOF) test can be used. The chi-square GOF test is often used to test the null hypothesis that a function describes the mean of the data well. The null hypothesis with this test is rejected too often, however, because the nominal significance level (usually 0.05) is exceeded. Alternatively, the level of Hotelling’s test is accurate...