Amphiphilic Ru(bpy)32+ complex (DC17Ru)—citratoperoxotitanate (CPT) —ditetradecylviologen (DC14V) triad nano-film was fabricated on quartz slab optical waveguide by organic-inorganic hybrid Langmuir-Blodgett method. Transient phosphorescence of the DC17Ru monolayer at 610 nm excited 532 pulsed laser observed SOWG spectroscopy. The partly quenched CPT layer and quenching enhanced DC14V underneat...

It is known that 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11), a semisynthesized derivative of camptothecin (CPT), has a potent antitumor activity in vivo, but 7-ethyl-10-hydroxycamptothecin (SN-38), a metabolite of CPT-11, shows much stronger cytotoxicity in vitro than CPT-11. In this study, we demonstrated that the relaxation of SV40 DNA plasmids by type I DNA to...

II Abstract ABSTRACT Miniature passive atomic frequency standard based on CPT resonance has been drawing more and more attentions in the fields of GPS, underwater navigation, unmanned vehicles, etc. This work focused on improving frequency stability of the CPT atomic frequency standard, and we have mainly carried out the study through two approaches: to reduce CPT signal linewidth by combining ...

Camptothecin (CPT) has anticancer activity. While only the lactone form of CPT is biologically active, this form exhibits poor aqueous solubility. Pharmaceutical formulation of CPT incorporated in liposomes is of significant importance to develop the therapeutic utilization of CPT. The aim of this study was to increase incorporation efficiency and stability of CPT in liposomes composed of hydro...

The successful treatments of brain tumors and many other brain disorders have been limited due to the presence of barricade from microvascular endothelium called the blood-brain barrier (BBB). It was estimated that over 98% of newly developed pharmaceutical drugs do not cross the BBB; therefore, it is necessary to develop methods to improve the delivery of drugs to the brain. In this investigat...

Soluble copolymers of camptothecin (CPT), based on poly[N-(2-hydroxypropyl) methacrylamide] (pHPMA), were obtained by conjugation through the degradable spacers -Gly-Phe-Leu-Gly- or -Gly-6-aminohexanoyl-Gly-. We investigated to what extent passive accumulation and retention of hydroxypropyl methacrylamide copolymer of CPT (pHPMA-CPT) in tumors and modulation of the drug release influence effica...

Camptothecin (CPT), a plant alkaloid with antitumor activity, is a specific inhibitor of eukaryotic DNA topoisomerase I. We have previously isolated and characterized a CPT-resistant topoisomerase I isolated from a CPT-resistant human leukemia cell line, CPT-K5. cDNA clones of topoisomerase I were isolated from the CPT-resistant and the parental CPT-sensitive cell lines, respectively. Sequencin...

this work presents free vibration analysis of laminated rectangular plates with classical boundary conditions based on the classical plate theory (cpt). the first involves an s-fgm plate with different boundary conditions. then involves a two-layer plate in which an s-fgm layer is coated on a homogeneous substrate with classical boundary conditions, simply called an s-fgm-coated plate; the othe...