Radiation therapy induces DNA damage and inflammation leading to fibrosis. Fibrosis can occur 4 to 12 months after radiation therapy. This process worsens with time and years. Radiation-induced fibrosis is characterized by fibroblasts proliferation, myofibroblast differentiation, and synthesis of collagen, proteoglycans and extracellular matrix. Myofibroblasts are non-muscle cells that can cont...

OBJECTIVES To compare the biological effects of 125I seeds continuous low-dose-rate (CLDR) radiation and 60Co γ-ray high-dose-rate (HDR) radiation on non-small cell lung cancer (NSCLC) cells. MATERIALS AND METHODS A549, H1299 and BEAS-2B cells were exposed to 125I seeds CLDR radiation or 60Co γ-ray HDR radiation. The survival fraction was determined using a colony-forming assay. The cell cycl...

OBJECTIVE Synchrotron radiation has shown high therapeutic potential in small animal models of malignant brain tumours. However, more studies are needed to understand the radiobiological effects caused by the delivery of high doses of spatially fractionated x-rays in tissue. The purpose of this study was to explore the use of the γ-H2AX antibody as a marker for dose deposition in the brain of r...

We studied the influence of low doses of γ radiation (from 0.04 to 1.8 mGy) on the stability of human red blood cells (RBC) from healthy donors and diabetic patients using absorption spectroscopy. Because of the alteration of many enzymatic pathways in diabetic RBCs resulting in strong modification of the lipid and protein membrane components one could expect that the ionizing γ-radiation shoul...

Micronuclei (MN) test is used as markers of radiosensitivity or chemosensitivity. In present study, it was investigated the frequency of MN in erythrocytes and body weight gain in 80 Mus musculus var. albinos exposed to 10 Gy gamma (γ) radiation and heavy metal ions. For this aim, it was used MN assay as an indicator of genotoxicity induced by γ–radiation and heavy metal toxication. The animals...

In order to examine radiation-induced proteins in an extremely radio-resistant bacterium, it became possibleto perform comparative proteomic analysis on radio-resistance Bacillus megaterium WHO as a wildtypestrain for the first time. Variation in cellular proteins profiles of the Bacillus megaterium WHO after 5KGy γ-irradiation were analyzed by two-dimensional poly acryl amide...

Gamma ray bursts (GRB’s) often feature subpulses that have a distinctively asymmetric profile – they rise quickly and decay much more slowly, while their spectrum softens slightly with observer time. It is suggested that these subpulses are caused by slow baryonic clouds embedded within a primary γ-ray beam, which scatter the γ-radiation into our line of sight as they accelerate. Good quantitat...

Recent High Energy Stereoscopic System (HESS) observations show that microquasars in highmass systems are sources of very high energy γ-rays. A leptonic jet model for microquasar γ-ray emission is developed. Using the head-on approximation for the Compton cross section and taking into account angular effects from the star’s orbital motion, we derive expressions to calculate the spectrum of γ ra...

Ionizing radiation-induced oxidative stress is attributed to generation of reactive oxygen species (ROS) due to radiolysis of water molecules and is short lived. Persistent oxidative stress has also been observed after radiation exposure and is implicated in the late effects of radiation. The goal of this study was to determine if long-term oxidative stress in freshly isolated mouse intestinal ...

Radiation therapy for oral and maxillofacial tumors could damage bone marrow stromal cells (BMSCs) in jaw, which caused dental implant failure. However, how radiation affects BMSCs on SLA (sandblasted with large-grits, acid-etched) surfaces is still unknown. The aim of this study was to investigate effect of different dose of γ-radiation on BMSCs on SLA and PT (polished titanium) surfaces. Rat ...