HEMORRHAGIC PANCREATITIS is a more lethal disease than edematous pancreatitis [2, 5, 81. For prognostic and therapeutic purposes it would be useful to be able to distinguish between the two forms of pancreatitis, but present methods are inadequate. Levels of serum amylase, an index of the degree of ductal obstruction of the pancreas, depend on a functioning acinar cell [l]. Amylase and lipase l...

Acute and chronic Plasmodium falciparum infections alter the immune competence of the host possibly through changes in dendritic cell (DC) functionality. DCs are the most potent activators of T cells, and migration is integral to their function. Mature DCs express lymphoid chemokine receptors (CCRs), expression of which enables them to migrate to the lymph nodes, where they encounter naïve T ce...

Direct electron spin resonance was used to detect tert-alkylperoxyl radicals generated by hematin and the corresponding hydroperoxides at near-physiological pH values. The spin-trapping method was necessary to detect the less persistent primary ethylperoxyl radical. Under a nitrogen atmosphere, the electron spin resonance signal of the tert-alkylperoxyl radicals decreased, and the ethylperoxyl ...

The Malaria Box, assembled by the Medicines for Malaria Venture, is a set of 400 structurally diverse, commercially available compounds with demonstrated activity against blood-stage Plasmodium falciparum. The compounds are a representative subset of the 20,000 in vitro antimalarials identified from the high-throughput screening efforts of St. Jude Children's Research Hospital (TN, USA), Novart...

Objective: The aim of this work was to establish pseudoternary phase diagrams for Palestinian basil extracts (seeds and leaves), formulate a microemulsion, study the antioxidant antimicrobial effects medicinal plant. Methods: Pseudoternary were prepared by utilizing water titration method, using leaves) as an oil phase. Basil analyzed its phytochemical constituents after it extracted Soxhlet ex...

1. It has been shown that powdered hematin is exceedingly resistant to the metabolic action of tissue cells, and wherever injected it will remain for weeks with but slight and slowly progressing alteration. 2. The changes produced in hematin by tissue cells are identical with those changes resulting from the oxidation of hematin by hydrogen peroxid, forming a series of bodies of decreasing colo...

BACKGROUND Emergence of chloroquine (CQ) resistance among different strains of Plasmodium falciparum is the worst catastrophe that has ever perplexed the dedicated efforts to eradicate malaria. This urged the scientists to search for new alternatives or sensitizers to augment its antiplasmodium effect. MATERIALS AND METHOD In this experiment, the potential of embelin, isolated from Embelia ri...

Plasmodium parasites degrade host hemoglobin to obtain free amino acids, essential for protein synthesis. During this event, free toxic heme moieties crystallize spontaneously to produce a non-toxic pigment called hemozoin or ß-hematin. In this context, a group of azole antimycotics, clotrimazole (CTZ), ketoconazole (KTZ) and fluconazole (FCZ), were investigated for their abilities to inhibit ß...