Protein aggregation and precipitation is associated with many debilitating diseases including Alzheimer's, Parkinson's, and light-chain amyloidosis. β-Casein, a member of the casein family, has been demonstrated to exhibit chaperone-like activity to protect protein form aggregation. Hofmeister salts (lyotropice series) are a class of ions which have an effect on the solubility and also the stab...

In this study, a novel adamantanamine-paclitaxel (AD-PTX) incorporated oligochitosan- carboxymethyl-β-cyclodextrin (CSO-g-CM-β-CD) self-assembly macromolecular (CSO-g-CM-β-CD@AD-PTX) micelle was successfully prepared in water through sonication. The formed molecules were characterized by Fourier transform infrared spectroscopy, proton nuclear magnetic resonance (NMR) spectroscopy, two-dimension...

This paper reviews the literature on the interactions of the caseins and suggests that the state of association of these proteins is governed by a balance of attractive hydrophobic interactions and electrostatic repulsion. The effects of temperature, pH and ionic strength on the self-association and calcium-induced aggregation of the individual caseins are rationalized in terms of their influen...

This research focused on understanding physical and chemical changes occurring to concentrated milk protein suspensions as a function of time. Skim (untreated heat treated at 90°C for 10 min) was 6 times the original volume using osmotic stressing, noninvasive concentration method, maintaining serum composition close possible that native milk. A protease inhibitor cocktail, with broad specifici...

Beta-casein (β-CN) is a major dairy protein subject to preferential degradation during storage. Our study aimed isolate β-casein from bovine milk under dissociative conditions by the electrophoretic technique using Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis (SDS-PAGE) and optimize an immunochemical such as Mancini radial immunodiffusion in order monitor evolution of this For purp...

Caseins, the main milk proteins, interact with colloidal calcium phosphate to form the casein micelle. The mesostructure of this supramolecular assembly markedly influences its nutritional and technological functionalities. However, its detailed molecular organization and the cellular mechanisms involved in its biogenesis have been only partially established. There is a growing body of evidence...