The relation of lysosomal enzymes to mammary tumor regression was studied in the highly hormone-dependent MTW9 rat mammary carcinoma. Quantities of the enzymes were determined with the use of a histochemical modification of the single radial immunodiffusion method. Major findings were as follows, (a) Acid phosphatase, arylsulfatase, ßgalactosidase, and 0-glucuronidase significantly increased i...

Increasing numbers of alterations have been found in protooncogenes (e.g., ras, mir), as well as tumor suppressor genes (e.g., p53, Rb) in various types of tumors. The multiple mutations cannot be explained by the spontaneous mutation rate. It has been suggested that mutator phenotypes leading to the accumulation of these mutations may be required in the early stages of tumorigenesis. To test t...

Two kinds of growth-inhibitory substances were found in culture of a Rous sarcoma virus-transformed rat liver cell line, RSV-BRL. The two substances were purified from the serum-free culture medium and iden tified as transforming growth factor ß, and Mycoplasma-áerÃ-\edarginine deiminase (EC 3.5.3.6), respectively. The arginine deiminase was an acidlabile but dithiothreitol-resistant protein ...

background: there is no published data on the association between serum biochemical and ultrasonographic markers and adverse pregnancy outcomes. therefore, the aim of this study was to determine the factors associated with perinatal outcomes in singleton pregnancies using ultrasound and maternal serum markers during the first trimester in panamanians. materials and methods: this was a prospecti...

2620 A Comparison of Some Ultrastructural and Biochemical Properties of Mitochondria from Morris Hepatomas 9618A, 7800, and 3924A. Peter L. Pederson, John W. Greenawalt, T. L. Chan, and Harold P. Morris. 2627 The Effect of 1-/3-D-Arabinofuranosylcytosine on Growth, Viability, and DNA Synthesis of Mouse L-cells. F. L. Graham and G. F. Whitmore. 2636 Studies in Mouse L-cells on the Incorporation ...

Hepatocyte growth factor/scatter factor (HGF/SF) is a stromallv de rived modulator of epithelial cell proliferation and morphology. To better assess the potential role of HGF/SF in tumor progression we sought to identify factors and biological conditions which regulate its expression. We show that several adult human primary fibroblast cultures from breast and prostate produce HGF/SF. HGF expre...

Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for the purpose medicinal products. With centuries had emerged as a magnanimous field science getting facelift from available natural compounds synthesis newer complex molecules possessing activity while transit earth synthetically furnished laboratory. Medicinal or pharmaceutical discipline at inters...

There has been little investigation of bacteria as gene delivery vectors. Here, we demonstrate that genetically engineered Salmonella have many of the desirable properties of a delivery vector, including targeting of multiple tumors from a distant inoculation site, selective replication within tumors, tumor retardation, and the ability to express effector genes, such as the herpes simplex virus...

A study of kinetic properties of mitochondria! ATPase in Morris hepatoma 3924A is reported. The results show that submitochondrial particles isolated from the tumor tissue exhibited a three-fold increase in both the A'mfor ATP hydrolysis and A', for the competitive inhibitor \ß,~t-imido\\11' " ¡ili regard to normal rat liver. Eadic-Hofstec analysis of the kinetics of ATP hydrolysis show that ...