The multifunctional protein ß-catenin governs as transcription factor the expression of a wide variety of genes relevant for cell proliferation and cell survival. In addition, ß-catenin is localized at the cell membrane and may influence the function of channels. The present study explored the possibility that ß-catenin participates in the regulation of the HERG K(+) channel. To this end, HERG ...

BACKGROUND Few studies have systematically investigated insomnia in adults with epilepsy. METHODS We performed a prospective cross-sectional investigation of the prevalence, severity, and comorbidities of insomnia in 90 adults with epilepsy using a battery of self-reported instruments and polysomnography. We quantified insomnia severity using the Insomnia Severity Index (ISI). RESULTS Fifty...

The Wnt/ß-catenin signaling pathway controls important cellular events during development and often contributes to disease when dysregulated. Using high throughput screening we have identified a new small molecule inhibitor of Wnt/ß-catenin signaling, WIKI4. WIKI4 inhibits expression of ß-catenin target genes and cellular responses to Wnt/ß-catenin signaling in cancer cell lines as well as in h...

The reporter gene for ß-galactosidase is frequently used to determine the efficiency of gene transfer in arteries. However, blood is often present in arterial explants and may compromise the results by the presence of hemoglobin. The light absorption of hemoglobin is similar to the absorption of several colorimetric products of the commonly used ß-galactosidase substrates, including onitropheny...

Bu çalışmanın amacı, Spor Bilimleri Fakültesinde (SBF) öğrenim gören öğrencilerin, öğrenme stili tercihleri ve öz kontrollü durumlarının akademik başarılarına etkisini araştırmaktır. Nicel araştırma yöntemlerinden, ilişkisel tarama modelinin kullanıldığı araştırmanın çalışma grubunu, SBF’de 2021-2022 yılda gören, kolay örnekleme yöntemi ile seçilen 348 gönüllü öğrenci oluşturmuştur. Çalışmada v...

Background: Magnetic resonance imaging (MRI) is becoming increasingly important in axial spondyloarthritis (SpA) due to its unique role early diagnosis, classification, and monitoring of disease (1, 2). It the only assessment tool that has been validated with histological inflammatory cellularity tissue biopsy sacroiliac (SI) joint (3). However, many MRI lesions are not exclusive SpA may occur ...

Understanding the antibiotic susceptibility of Salmonella enterica is important both from a clinical treatment and a public health perspective. The emergence of extended spectrum ß-lactamases (ESßLs) and AmpC ß-lactamases in S. enterica is important, as this will limit treatment options and could provide a strain with a significant selective advantage. The aim of the study was to screen isolate...

Odontogenic keratocyst is now designated by the World Health Organization as a keratocystic odontogenic tumor (KCOT). According to recent reports Wnt pathway and ß-catenin are involved in the pathogenesis of the majority of odontogenic and neoplastic lesions. The aim of this study was to evaluate the expression of ß-catenin in KCOT and compare it with those of dentigerous cyst and ameloblastoma...

The proper localization of ß-actin mRNA and protein is essential for growth cone guidance and axon elongation in cultured neurons. In addition, decreased levels of ß-actin mRNA and protein have been identified in the growth cones of motor neurons cultured from a mouse model of Spinal Muscular Atrophy (SMA), suggesting that ß-actin loss-of-function at growth cones or pre-synaptic nerve terminals...

Burnout is associated with poor mental and physical functioning and high costs for societies. Personality attributes may critically increase the risk of personal burnout. We specifically examined whether narcissism associates with personal burnout in a working population. We studied n=1,461 employees (mean age 41.3 ± 9.4 yr, 52% men) drawn from a random sample of a pharmaceutical company in Ger...