Transient receptor potential ankyrin1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1) are members of the TRP superfamily of structurally related, nonselective cation channels and mediators of several signaling pathways. Previously, we identified methyl syringate as an hTRPA1 agonist with efficacy against gastric emptying. The aim of this study was to find hTRPA1 and/or hTRPV1 activ...

Bacterial resistance has been increasingly reported worldwide and is one of the major causes of failure in the treatment of infectious diseases. Natural-based products, including plant secondary metabolites (phytochemicals), may be used to surpass or reduce this problem. The objective of this study was to determine the antibacterial effect and mode of action of selected essential oils (EOs) com...

Abstract Anethum graveolens L. (Dill) is an aromatic, medicinal, and food plant that widely known in the world. This paper presents results of study essential oil A. graveolens, which was cultivated Stavropol region (Russia, North Caucasus) to restore its growth. Herb variety “Scythian”, collected different fields limited company “Cossack agriculture “Staropavlovskoe”. The obtained by Clevenger...

The essential oil obtained by steam distillation of dried aerial parts of Ambrosia trifida L. from Northeast China was analyzed by GC and GC-MS. The essential oil yield based on dried plant material was 0.12% and thirty-five compounds (corresponding to 86.7% of the total weight) were identified. The main components were: bornyl acetate (15.5%), borneol (8.5%), caryophyllene oxide (8.3%), alpha-...

Iron-mediated oxidative cyclisation provides an efficient approach to pyrano[3,2-a]carbazole alkaloids. Thus, improved routes to girinimbine and murrayacine as well as the first total syntheses of O-methylmurrayamine A and 7-methoxymurrayacine are reported. Asymmetric epoxidation of girinimbine led to (-)-trans-dihydroxygirinimbine and the assignment of its absolute configuration.

Novel coronavirus which was named later as SARS-CoV2 appeared in Wuhan, China, the end of December 2019. Actually, no precise drugs are existed and research concerning treatment is deficient. main protease (Mpro) crystallized by Liu et al. (2020) represented a crucial drug target. The present work aimed to evaluate some bioactive compounds from Pistacia atlantica possible Mpro inhibitors, based...