Three experiments were conducted using crossbred weanling pigs (7.2 to 8.6 kg; 25 to 29 d of age) to determine the effect on performance and nutrient digestibility of .75% yeast culture (YC) additions to starter diets containing whey or one of two fiber sources. An 18% CP corn-soybean meal basal diet was used in all experiments. In Exp. 1 (n = 192), the addition of YC did not affect ADG, ADFI, ...

Although much has been learned about the role of the amygdala in Pavlovian fear conditioning, relatively little is known about the signaling pathway involved in the acquisition of an active avoidance reaction. The aim of this study is to investigate the potentiating effects of the NO-guanylate cyclase activator YC-1 on learning and memory of shuttle avoidance test in rats. YC-1 enhanced the ind...

A major limitation to successful cancer treatment is the existence of drug resistance. While several mechanisms of drug resistance have now been well characterized, mechanisms of resistance to alkylating drugs have remained less well defined. Several experimental models of alkylator resistance have implicated isoforms of glutathione S-transferase (GST) but transfection experiments using cloned ...

AIM To investigate the protective effect of medical ozone (O(3)) combined with Traditional Chinese Medicine (TCM) Yigan Fuzheng Paidu Capsules (YC) against carbon tetrachloride (CCl(4))-induced hepatic injury in dogs. METHODS Thirty healthy dogs were divided randomly into five groups (n = 6 in each group), namely control, oleanolic acid tablet (OAT), O(3), YC and O(3) + YC, given either no pa...

Our previous study demonstrated that 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) might activate the soluble guanylate cyclase (sGC)/cGMP/protein kinase G (PKG) pathway to induce cyclooxygenase-2 (COX-2) expression in human pulmonary epithelial cells (A549). In this study, we further investigated the role of Raf-1 in YC-1-induced nuclear factor-kappaB (NF-kappaB) activation and COX-2 e...

Oral cancer is a serious and fatal disease. Cisplatin is the first line of chemotherapeutic agent for oral cancer therapy. However, the development of drug resistance and severe side effects cause tremendous problems clinically. In this study, we investigated the pharmacologic mechanisms of YC-1 on cisplatin-resistant human oral cancer cell line, CAR. Our results indicated that YC-1 induced a c...

DENEV, S. A., Tz. PEEVA, P. RADULOVA, P. STANCHEVA, G. STAYKOVA, G. BEEV, P. TODOROVA and S. TCHOBANOVA, 2007. Yeast cultures in ruminant nutrition. Bulg. J. Agric. Sci. 13: 357-374 Interest in the use of fungal direct-fed microbials in ruminant nutrition is considerable. The ban of antibiotic growth promoters in feed for production of animal foods has increased interest in evaluating the effec...

Background: YC-1 (3-(5'-hydroxymethyl-2'furyl)-1-benzyl-indazole) is an allosteric activator of soluble guanylyl cyclase (sGC) and a vasodilator. This study describes a paradox action of YC-1 in isolated vessels of coronary artery disease (CAD) patients which appears to trigger an endothelium-dependent vasoconstrictor pathway present in vessels with endothelial dysfunction. Methods: Effects of ...

1. One of the main problems in the field of multifunctional proteins such as ligandin is the possibility that multiple forms and isoproteins may exist. Because liver ligandin [GSH (reduced glutathione) S-transferase B] consists of equal amounts of Ya (22 000 Da) and Yc (25 000 Da) subunits, and testis ligandin, prepared by the standard technique of anion-exchange and molecular-exclusion chromat...

Inhibition of HIF-1a activity provides an important strategy for the treatment of cancer. Recently, 3-(5 0-hydroxymethyl-2 0–furyl)-1benzyl indazole (YC-1) has been identified as an anti-HIF-1a drug in cancer therapy with unclear molecular mechanism. In the present study, we aimed to investigate the effect and mechanism of YC-1 on HIF-1a in a hepatocellular carcinoma cell line under hypoxic con...