BACKGROUND Pregabalin has shown remarkable antinociceptive effects in neuropathic pain; however, its efficacy against acute and visceral pain remained controversial. OBJECTIVES The present study aimed at investigating the involvement of N-methyl-D-aspartate (NMDA) receptors in the antinociceptive effect of pregabalin in both acute and visceral pain using and comparing hot plate test and writh...

Methanolic extract of Solanum trilobatum Linn. (MEST) belonging to the family of Solanacea was evaluated by hot plate and acetic acid induced writhing methods to assess its analgesic activity. The extract was also evaluated for its anti-inflammatory activity by subjecting into carrageenan, and cotton pellet induced granuloma tests for its effect on acute and chronic phase inflammation models in...

The present study evaluates the central and peripheral analgesic activity of ethanolic extract of Cananga Odorata Lam [EECO] in experimental animals.Acute toxicity test was done following OECD guidelines. EECO (100mg/kg, 200mg/kg and 400mg/kg b.w. p.o) was evaluated for central and peripheral analgesic activity by the Tail flick method in wistar rats and 0.7%acetic acid induced Writhing test in...

In the present biological studies, several pharmacological investigations were carried out to ascertain analgesic, and antioxidant activity of the ethanol extract of the leaves of Cerbera manghas Linn. (FamilyApocynaceae). The presence of reducing sugars, tannins, steroids, alkaloids, glycosides, and flavonoids were indicated by the phytochemical analysis of the extract. To evaluate analgesic a...

The antinociceptive activity of the methanolic extract of the leaves of Feronia limonia Linn. (Family Rutaceae) was investigated using acetic acid-induced writhing model and tail flick test in swiss albino mice. The extract produced about 26.01% ( p< 0.01), 39.88% ( p< 0.01) and 57.07% (p< 0.01) writhing inhibition at the dose of 100, 200 and 400 mg/kg of body weight respectively, which was com...

The antinociceptive activity of the crude extract and fractions of Stryphnodendron adstringens (Martius) Coville (barbatimão) was evaluated. Three experimental models of pain induction were used: abdominal writhing, formalin, and hot plate. The results demonstrated an antinociceptive effect of barbatimão in the experimental models of writhing induced by acetic acid and pain induced by formalin....

The analgesic activity of the methanol extract of Phyllanthus lawii (MEPL) was investigated in Swiss albino mice with hot plate and acetic acid induced writhing models. The results suggested that MEPL possess potent analgesic activity. The MEPL produced a significant decrease in mice writhing induced by acetic acid suggesting peripheral analgesic activity and elevated mean basal reaction time i...

Glycyrrhetinic acid (Ia) and fourteen derivatives of glycyrrhetinic acid were examined to estimate the antinociceptive activity (tests on writhing and vascular permeability induced by 0.7% acetic acid) and anti-type IV allergic effects in mice. Among them, three dihemiphthalate compounds (IIf, IIIc, IVc) derived from, deoxoglycyrrhetol (IIa), showed strong inhibition of writhing and dye leakage...