OBJECTIVE To assess the efficacy of intraarticular (IA) injections of hyaluronic acid (HA) compared to placebo in patients with osteoarthritis (OA) of the knee; and to assess patient satisfaction with treatment relative to placebo, and whether there is a difference between a series of 3 versus 6 consecutive IA injections. METHODS We conducted a randomized, double-blind, placebo controlled, 2-...

BACKGROUND Currently, though pharmacological, mechanical, and surgical interventions are used, there is no known cure for osteoarthritis (OA). OBJECTIVES The main aim of the study was to assess the efficacy and safety of "TLPL/AY/03/2008", a polyherbal formulation on knee joint pain assessed on visual analogue scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOM...

PURPOSE To compare the short-term outcome of the Multigen Plus system using a symmetric ceramic femoral component with that of 2 metallic total knee replacement (TKR) systems. METHODS 60 patients (62 knees) with osteoarthritis or rheumatoid arthritis underwent primary TKR using the Genia system (n=20), the Multigen Plus system (n=17), and the Multigen Plus system with a ceramic femoral compon...

OBJECTIVE To evaluate the safety and efficacy of ketoprofen in Transfersome® gel (IDEA-033) in comparison with a ketoprofen-free vehicle (TDT 064) for the treatment of osteoarthritis (OA) of the knee. METHODS Patients with knee OA (N = 866) were randomly assigned to receive topical IDEA-033 containing 100, 50, or 25 mg ketoprofen, or TDT 064 twice daily for 12 weeks, in a double-blind trial. ...

BACKGROUND There is growing concern about the use of opioids prior to total knee arthroplasty (TKA), and research has suggested that preoperative opioid use may lead to worse pain outcomes following surgery. We evaluated the pain relief achieved by TKA in patients who had and those who had not used opioids use before the procedure. METHODS We augmented data from a prospective cohort study of ...

background: knee osteoarthritis is a common degenerative joint disorder and a major cause of pain and disability. recent studies have suggested that bisphosphonates such as alendronate may have a role in the treatment of osteoarthritis. the purpose of the present study was to investigate the potential effect of alendronate on the symptoms of knee osteoarthritis.  methods: thirty nine patients w...

Aim: To determine whether hyaluronan (HA) delays and/or reduces the knee replacement surgery (KRS) in patients with osteoarthritis (OA). Material and Methods: A prospective, single-center, double-blind, randomized, placebo-controlled, pilot clinical trial with two treatment groups [HA (Adant ® ) treatment group and placebo treatment group] was conducted. The intra-articular treatments (HA or pl...

OBJECTIVE Early detection of osteoarthritis (OA) would increase the chances of effective intervention. We aimed to investigate which patient-reported activity is first associated with knee pain. We hypothesized that pain would occur first during activities requiring weight bearing and knee bending. METHODS Data were obtained from the Osteoarthritis Initiative (OAI), a multicenter, longitudina...

introduction intra-articular injections of platelet rich plasma (prp) for the treatment of knee osteoarthritis have been shown to reduce pain and improve joint function. the aim of this study is to examine the joint function by adding intra-articular growth hormone to platelet rich plasma. this study was performed on the individuals with knee osteoarthritis and under ultrasound guidance. conclu...