Microemulsions are clear, stable, isotropic mixtures of oil, water and surfactant, frequently in combination with a cosurfactant. These systems are currently of interest to the pharmaceutical scientist because of their considerable potential to act as drug delivery vehicles by incorporating a wide range of drug molecules specially BCS Class-II and Class-IV. In order to appreciate the potential ...

Electrolysis in microemulsions is a promising approach for environmentally friendly chemical synthetic methods of the future. Employing microemulsions instead of organic solvents for electrosynthesis has the advantages of lower toxicity and cost, high dissolving power for reactants and mediators of unlike solubility, enhancement of reaction rates by controlling the reduction potentials of media...

New fluorinated microemulsions (F-MEs) formulated from partially fluorinated solvent–co-solvent mixtures and fluorinated anionic AOT-analogue surfactants are reported. These F-MEs permit incorporation of water into fluorinated solvents, up to a volume fraction fwater z 0.13. Interestingly, phase behavior and structures, determined by small-angle neutron scattering (SANS), parallel many other cl...

Recently we showed how crystallization in microemulsions could lead directly to the most stable polymorph, thereby leapfrogging Ostwald’s rule of stages. Here we consider in more details the crystallization of mefenamic acid from dimethylformamide microemulsions. Crystallization of mefenamic acid from bulk DMF has previously been shown to produce only the metastable Form II irrespective of the ...

Resveratrol is well known for its antioxidant activity and susceptibility to ultraviolet radiation. Development of formulations providing improved stability and relevant drug delivery of resveratrol is still a challenging task. The aim of this study was to determine protective characteristics of formulated microemulsions by evaluating photoisomerization of resveratrol and to investigate the eff...

Nanoparticles of silver halides are widely used to study the quantum confinement effects in indirect band gap semiconductors [1]. These particles are typically prepared by carrying out a precipitation reaction in the water pools of w/o microemulsions, or reverse micelles, by mixing two identical microemulsions containing aqueous solutions of AgNO3 and KBr, or other halides [2]. The mixing of tw...

The effect of a polymer, polyethylene glycol with a molecular weight of 400 (PEG-400), on the dynamics of solvent and rotational relaxation have been investigated in [bmim][BF4]/TX100/cyclohexane microemulsions using steady state and time resolved fluorescence spectroscopy as a tool and coumarin 480 (C-480) as a fluorescence probe. The size of the microemulsions increases with addition of PEG-4...

The structure of microemulsions prepared by the anionic gemini surfactant didodecyl diphenyl ether disulfonate (C12-DADS) was investigated by a solvatochromic probe and nuclear magnetic resonance (NMR) diffusion measurements. The NMR measurements indicate the presence of bicontinuous and oil-in-water microemulsions depending on microemulsion composition. The absorbance spectra of the solvatochr...

Combinations of lecithin with hydrophilic (e.g. C8-PEG) and lipophilic (e.g. sorbitan monooleate) linkers (unbalanced amphiphiles) have been used to produce microemulsions with a wide range of oils. The resulting microemulsions have been found to be biocompatible through a number of tests, including cell viability tests, Human Repeat Insult Patch Test (HRIPT), and Ames test. In this presentatio...

Microemulsions are physically stable oil/water systems that have potential use as delivery systems for many pharmaceuticals which are normally of limited use due to their hydrophobicity, toxicity or inability to access the site of action. It has been suggested that microemulsions are self-preserving antimicrobials in their own right, although there is little evidence to support this. In this ex...