(NTS) in Wistar rats (WR) and spontaneously hypertensive rats (SHR), our previous results suggested that sustained hypertension might aggravate the nephrotoxic processes or protract the course of glomerulonephritis. The present study was attemped to observe the more prolonged glomerular changes of nephrotoxic nephritis (NTN) until 15 weeks after the injection of NTS in SHR, compared with contro...

objective(s): nitric oxide (no), a product of inducible nitric oxide synthase (inos), contributes in germ cell apoptosis. this study was aimed to evaluate the effects of aloe vera gel (avg) on male wistar rat reproductive organ, serum no level, and expression of inos gene in leydig cells. materials and methods:adult male wistar rats (n=36) were used for experiments in three groups. the experime...

objective(s): titanium dioxide (tio2) nanoparticles (nps) are widely used in commercial food additives and cosmetics worldwide. uptake of these nanoparticulate into humans by different routes and may exhibit potential side effects, lags behind the rapid development of nanotechnology. thus, the present study designed to evaluate the toxic effect of mixed rutile and anatase tio2 nps on serum bioc...

In-vivo Magnetization Transfer Imaging of Mouse Lungs using a Zero Echo Time Sequence at 4.7 T – initial Experience. Moritz C Wurnig, Mingming Wu, Wolfgang Jungraithmayr, Markus Weiger, Klaas P Pruessmann, and Andreas Boss Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Zurich, Switzerland, Institute for Biomedical Engineering, University and Swiss Fede...

Acetaldehyde (ACD) is the first metabolite of ethanol. Although, the role of ACD in ethanol addiction has been controversial, there are data showing a relationship. The objective of the current study was to further test the hypothesis that ACD itself is reinforcing. For this reason, we carried out a study on operant oral ACD self-administration. Wistar rats were trained to self-administer tap w...

The objective of the present study was to evaluate sphingolipid levels (sphingosine-So and sphinganine-Sa) and to compare the Sa/So ratio in liver, serum and urine of Wistar rats after prolonged administration (21 days) of fumonisin B(1) (FB(1)). In parallel, the kinetics of sphingolipid elimination in urine was studied in animals receiving a single dose of FB(1). Prolonged exposure to FB(1) ca...

Wistar rats were exposed to a 916 MHz, 10 W/m(2) mobile phone electromagnetic field for 6 hours a day, 5 days a week. Average completion times in an eight-arm radial maze were longer in the exposed rats than control rats after 4-5 weeks of exposure. Error rates in the exposed rats were greater than the control rats at 6 weeks. Hippocampal neurons from the exposed rats showed irregular firing pa...

In the present study, the effect of minocycline was studied against intracerebroventricular streptozotocin induced spatial memory deficit. Male wistar rats were injected with intracerebroventricular streptozotocin bilaterally. The rats were treated chronically with Minocycline (10, 20 and 40 mg/kg, ip) for 17 days starting from day 1 of streptozotocin injection in separate groups. The spatial m...

By WILLIAM C. MOLONEY, ANTONIO E. BOSCHETFI AND GERALDINE Down T HIS INVESTIGATION is concerned with studies on leukemia occurring in a series of noninbred Wistar and inbred Wistar Furth ( W/Fu ) rats treated with whole body x-ray and oral administration of 3 methylcholanthrene ( 3MCA ) . The animals were followed by serial leukocyte counts and examination of peripheral blood smears. At the tim...

BACKGROUND Every year, millions of people are exposed to avoidable, life-threatening risks through the trans-fusion of unsafe blood. AIM To determine the survival time of Treponema pallidum in banked donor blood. MATERIAL AND METHODS Two groups of male Wistar rats (group A and B) were inoculated intratesticularly with 0.5ml of artificially infected donor blood (final density of Nichols trep...