The endocannabinoid system and the cannabinoid CB(1) receptors are involved in the development of ethanol tolerance and dependence. This study aimed to investigate the in vivo sensitivity of a CB(1) receptor agonist (WIN 55,212-2) modulating the synthesis of 3,4-dihydroxy-phenylalanine/dopamine/noradrenaline (DOPA/DA/NA) and that of 5-hydroxy-tryptophan/serotonin (5-HTP/5-HT) in rat brain after...

We prove that for any constant k and any < 1, there exist bimatrix win-lose games for which every -WSNE requires supports of cardinality greater than k. To do this, we provide a graphtheoretic characterization of win-lose games that possess -WSNE with constant cardinality supports. We then apply a result in additive number theory of Haight [8] to construct win-lose games that do not satisfy the...

The Minority Game is a model of interacting agents, who try to choose between two options every day, and those who are in the minority are winners. In an earlier paper, efficient stochastic strategies for this game was analyzed when the number of agents is 3, 5, 7. When the number of agents is large, the behaviour is qualitatively different, and as the discount parameter is varied, there is a s...

This article examines possibilities to develop the service sector in a peripheral area by using virtual business incubations instead of traditional, location-based business incubations. The article introduces typical characteristics of physical business incubations and compares them with features that are possible to be provided also virtually. Then, using the tourism branch in Finnish Lapland ...

Wer hätte vor drei Jahren gedacht, dass diese Diskussion in der Branche Alten- und Pflegeheime wieder geführt werden muss? Doch die Pandemie Auswirkungen des zunehmenden Personalmangels lassen Fragen rund um Aufwand-Nutzen-Relation Qualitätsmanagements erneut aufflammen. Was Qualitätsmanagement nun wirklich bringt welche Qualitätsarbeit für eine krisengeprägte hat, beleuchten Vertreterinnen Ver...

Cannabinoids suppress nociceptive processing of acute stimuli, but little is known about their effects on processes that lead to hyperexcitability of nociceptive neurons following prolonged noxious stimulation. Wind-up, the increasingly strong response of spinal nociceptive neurons to repetitive noxious electrical stimuli, results from a fast-rising cumulative depolarization and increase in int...