Background: The study of rheological properties of blood has special interest since it is a circulating fluid exposed to shear rates during its life time. This work aims to investigate the influence of whole body gamma irradiation on the rheological properties of rat’s blood. The applied shear rate was from 12 to 375 s-1. Low shear viscosity (up to 100 s-1) depends mainly on the erythroc...

Mefloquine, as a racemic mixture, is used for the treatment and prophylaxis of malaria. Stereoselective pharmacodynamic and pharmacokinetic differences has been observed for mefloquine. In this study a modified stereoselective HPLC method is presented for determination of mefloquine (MFQ) enantiomers in whole blood. The assay involved liquid-liquid extraction of MFQ from biological fluids with ...

The sequences of events regulating thrombin generation during tissue factor-initiated clotting in whole blood at 37°C in which the contact pathway was suppressed with corn trypsin inhibitor are studied using quantitative Western blotting of factor V, prothrombin, platelet factor 4, antithrombin Ill, and fibrinogen. In addition, fibrinopeptide A (FPA), thrombin-antithrombin 111 (TAT) complex for...

BLOOD has anomalous rheological properties, particularly in certain disease states. It may therefore be necessary to consider these properties when attempting to assess and perhaps to improve the state of a patient's cerebral circulation. So what evidence is there that cerebral blood flow (CBF) is affected by viscosity? Before attempting to answer this question, one should be aware of what infl...

The sequences of events regulating thrombin generation during tissue factor-initiated clotting in whole blood at 37 degrees C in which the contact pathway was suppressed with corn trypsin inhibitor are studied using quantitative Western blotting of factor V, prothrombin, platelet factor 4, antithrombin III, and fibrinogen. In addition, fibrinopeptide A (FPA), thrombin-antithrombin III (TAT) com...