The posterior lateral line primordium (pLLp) migrates caudally and periodically deposits neuromasts under the skin in the zebrafish trunk and tail. Each neuromast, formed within the migrating pLLp, has a central atoh1-positive hair cell determined by Notch mediated-lateral inhibition. The generation of new neuromasts and their deposition as the pLLp migrates caudally is coordinated by mutually ...

Abstract Aims Obstructive sleep apnoea (OSA) has been implicated in the pathophysiology of Alzheimer’s disease (AD). Intermittent hypoxia and arousals may contribute to mechanisms leading accumulation amyloid beta plaques intraneuronal neurofibrillary tangles seen AD. Treatment with Continuous Positive Airway Pressure (CPAP) improves symptoms cardiovascular sequalae OSA, also mitigate progressi...