Thirty nine very low birthweight neonates (with a birth weight of 820 to 1500 g and gestation of 27 to 34 weeks) who required total parenteral nutrition were randomly assigned to one of three regimens of administration of fat emulsion for a period of eight days. Groups 1 and 2 received the emulsion at a constant rate over 24 and 16 hours, respectively, beginning with a daily dosage of 1 g/kg an...

Reports on the influence of fructose on blood alcohol clearance have not always been consistent. Notwithstanding, information concerning the Nigerian population is yet to be documented. In this present study, ten consenting adults in apparent sound health, and who did not have any traceable history of alcohol or drug abuse were selected. The subjects were non-smoking Nigerians with an average a...

PURPOSE The aims were to assess the safety, pharmacokinetics, maximum tolerated dose, and antitumor activity of AMG 102, a fully human hepatocyte growth factor/scatter factor (HGF/SF)-neutralizing monoclonal antibody, in patients with solid tumors. EXPERIMENTAL DESIGN Patients (N = 40) with refractory advanced solid tumors were enrolled into six sequential dose-escalation cohorts (0.5, 1, 3, ...

AIMS: Cachexia, the wasting disorder associated with a wide range of serious illnesses including cancer, is a major cause of morbidity and mortality. There is currently no widely approved therapeutic agent for treating or preventing cancer-associated cachexia. Colorectal cancer and non-small cell lung cancer have relatively high incidences of cachexia, approximately 28% and 34%, respectively. N...

BACKGROUND/OBJECTIVES In nutritional epidemiology, collecting self-reported respondent height and weight is a simpler procedure of data collection than taking measurements. The aim of this study was to compare self-reported and measured height and weight and to evaluate the possibility of using self-reported estimates in the assessment of nutritional status of elderly Poles aged 65 + years. S...

The c-Jun N-terminal kinase (JNK)-inhibiting peptide D-JNKI-1, syn. XG-102 was tested for its therapeutic potential in acute inflammatory bowel disease (IBD) in mice. Rectal instillation of the chemical irritant trinitrobenzene sulfonic acid (TNBS) provoked a dramatic acute inflammation in the colon of 7-9 weeks old mice. Coincident subcutaneous application of 100 µg/kg XG-102 significantly red...

Documenting the burden and risk factors for perinatal asphyxia-related mortality is key to its prevention. The goal was document associated with in asphyxia a tertiary health facility Nigeria. Records of consecutive neonatal admissions (between January 2016 2017) underwent retrospective analysis. Data were analyzed using Stata statistical software version 16 (Statacorp® Texas, USA). 102 (12.1%)...

BACKGROUND Ideal body weight (IBW), which can be calculated using the variables of true height and sex, is important for drug dosing and ventilator settings. True height often cannot be measured in the emergency department (ED). OBJECTIVES Determine the most accurate method to estimate IBW using true height-based IBW that uses true height estimated by providers or patients compared to true he...

PURPOSE This phase Ib study evaluated the safety, pharmacokinetics, pharmacodynamics, and antitumor activity of AMG 102, a fully human monoclonal antibody against hepatocyte growth factor/scatter factor (HGF/SF), in combination with bevacizumab or motesanib in patients with advanced solid tumors. EXPERIMENTAL DESIGN Patients with treatment-refractory advanced solid tumors were sequentially en...

in many crops, incorrect management of nitrogen and water is one of the most important factors in the resources productivity such as water and nitrogen. in order to evaluate the effects of different nitrogen levels (zero, 50, 100 and 150 kg ha-1) and irrigation application rates (100, 75 and 50% of water requirement per species) on corn, sesame and sugar beet, three separate experiments was con...