OBJECTIVE Clozapine is the first choice in drug-resistant schizophrenia but also causes important weight changes. This might discourage clinicians concerned about the risk of developing health problems. To assess this issue we measured change in body mass index (cBMI) induced by clozapine at 18 and 56 weeks. METHODS Baseline body weight and height were measured and weight weekly thereafter du...

The influence of two carbon sources, sorbitol and sucrose on In vitro shoot proliferation and rooting of peach rootstock GF 677 was compared at 15, 30, 45 and 60 g l concentrations. The highest number of shoots per proliferated explant, usable shoots and shoots having maximum fresh weight were obtained on sorbitol at 30 g l. GF 677 does not seem to be an efficient utilizer of sucrose for In vit...

OBJECTIVES The chemokine receptors CCR2 and CX3CR1 are important in the development of coronary artery disease. The purpose of this study is to analyze the effect of a novel CCR2 inhibitor in conjunction with CX3CR1 deletion on vascular inflammation. METHODS The novel CCR2 antagonist MRL-677 was characterized using an in vivo model of monocyte migration. To determine the relative roles of CCR...

OBJECTIVE Obesity is one of the major health challenges throughout the world. The association between obesity and diabetes is well established because 90% of patients with type 2 diabetes mellitus (T2DM) show excess body weight. The aim of the study was to evaluate the effect of laparoscopic sleeve gastrectomy (LSG) on morbid obesity and type 2 diabetes (T2DM) in the long-term follow-up. METH...

OBJECTIVE Evaluate the safety and efficacy of bariatric surgery in older patients. BACKGROUND Because of an increased morbidity in older patients who may not be as active as younger individuals, there remain concerns that they may not tolerate the operation well or lose adequate amounts of weight. METHODS The database of patients who had undergone bariatric surgery since 1980 and National D...

FLT3 has been identified as a valid target for the treatment of acute myeloid leukemia (AML), and some FLT3 inhibitors have shown very good efficacy in treating AML in clinical trials. Nevertheless, recent studies indicated that relapse and drug resistance are still difficult to avoid, and leukemia stem cells (LSCs) are considered one of the most important contributors. Here, we report the char...

OBJECTIVE To assess the effects of radiation dose reduction in the chest CT using a weight-based adjustment of the automatic exposure control (AEC) technique. MATERIALS AND METHODS With Institutional Review Board Approval, 60 patients (mean age, 59.1 years; M:F = 35:25) and 57 weight-matched patients (mean age, 52.3 years, M:F = 25:32) were scanned using a weight-adjusted AEC and non-weight-a...

Two lines of rabbits divergently selected for body weight at 63 days during 6 generations (H: high line; L: low line) and a cryo-preserved control group (C) were used to assess the effects of growth rate on muscle characteristics, either at a fixed age (63 days) or at the same weight (2297 + 10 g). In the two series of slaughter, body weight at weaning (28 days) was decreased in the rank order ...

BACKGROUND The optimal common channel (CC) length for malabsorptive weight loss surgeries is unknown even though these surgeries were developed in the 1970s (biliopancreatic diversion [BPD]) and the 1990s (biliopancreatic diversion with a duodenal switch [BPD DS]). We hypothesized that the length of the CC correlates with a successful weight loss result. METHODS We evaluated 3 groups of patie...

A study involving 825 spring ewe lambs was conducted to evaluate effects of breed, heterosis, type of birth and rearing, age of dam and preweaning and postweaning growth rate on occurrence of puberty before November 10. Within a breed or breed-cross, preweaning competition among twin and triplet lambs reduced lamb weights by 4 or 5 kg at 70 (weaning), 160 and 230 days of age and by about 3 kg a...