Orofacial granulomatosis (OFG) is a granulomatous disease of the orofacial region which appears usually as a persistent and/or recurrent labial soft tissue swelling in the orofacial region and is characterized histologically by a granulomatous inflammation. OFG may cause significant cosmetic and functional problems but can be prevented if the disease is diagnosed early and promptly treated. Thi...

Wegener's granulomatosis of the pituitary gland resulting in diabetes insipidus is a rare complication of the disease. Standard treatment for Wegener's granulomatosis involves a combination of prednisolone and cylophosphamide, however biologic agents are now being used in refractory cases. We report three cases of patients with diabetes insipidus as a complication of Wegener's granulomatosis wh...

Granulomatosis with polyangiitis (GPA, formerly known as Wegener's Granulomatosis) is an autoimmune small vessel vasculitis which is highly associated with anti-neutrophil cytoplasmic antibodies (ANCA). The hallmarks of this condition are systemic necrotising vasculitis, necrotising granulomatous inflammation, and necrotising glomerulonephritis. The aetiology of granulomatosis with polyangiitis...

Wegener's granulomatosis or granulomatosis with polyangiitis is a necrotizing vasculitis affecting both arterioles and venules. The disease is characterized by the classical triad involving acute inflammation of the upper and lower respiratory tracts with renal involvement. However, the disease pathology can affect any organ system. This case presents Wegener's granulomatosis presenting with fa...

Granulomatous lung diseases are a heterogeneous group of disorders that have a wide spectrum of pathologies with variable clinical manifestations and outcomes. Precise clinical evaluation, laboratory testing, pulmonary function testing, radiological imaging including high-resolution computed tomography and often histopathological assessment contribute to make a confident diagnosis of granulomat...

Lymphomatoid granulomatosis is an uncommon disorder that can present as multiple pulmonary nodules. Systemic manifestations such as fever, weight loss, skin lesions, and other organ involvement may occur. The clinical presentation of lymphomatoid granulomatosis can mimic infectious diseases (eg, tuberculosis), vasculitis, or metastatic malignancies.1 Lymphomatoid granulomatosis should be consid...

2. Guiñazú Álvarez A, Matteoda M, Tempra A. Granulomatosis linfomatoidea: manifestaciones pulmonares de una entidad infrecuente. RAR. 2006;70:289–92. 3. Frazier AA, Rosado-de-Christenson ML, Galvin JR, Fleming MV. Pulmonary angiitis and granulomatosis: radiologic–pathologic correlation. Radiographics. 1998;18:687–710. 4. Ammannagari N, Gao Z, Deng C, O’Connor O. Lymphomatoid granulomatosis: a d...

Intravenous injection of powdered tablets intended to oral use is a common practice among drug abusers, given the greater effectiveness attributed to accelerate delivery of the drug through this route compared to oral intake. This can result in both acute and chronic changes in the pulmonary vessels and parenchyma. Various terms have been used to describe this entity and include self-induced pu...

Differential diagnosis of infection during active immune disease, such as Wegener's granulomatosis (Wegener's granulomatosis), is a major clinical challenge. Laboratory measures, erythrocyte sedimentation rate or C-reactive protein, can be elevated in infections that supervene, or coinciding with, in active Wegener's granulomatosis, and thus are nonspecific. The aim of the study was to compare ...

Bronchocentric granulomatosis was first described in 19731 and is characterised by a necrotising granulomatous destruction of bronchial walls, bronchioles, and adjacent lung parenchyma. The bronchial lumen is filled by debris and cells, predominantly eosinophils in asthmatic patients and polymorphonuclear leucocytes in non-asthmatic patients.2 Proximal bronchi may show severe chondritis. Any va...