Background and Aim: Orexin is a hormone involved inoverweight and obesity and a regulator of glucose metabolism. The purpose of this study was to determine the effects of a high-intensity interval training (HIIT) on plasma levels of orexin-A (OXA) and insulin resistance in overweight women. Materials and Methods: In a semi-experimental study, 24 overweight women (aged 20-25 years; body mass in...

Background and Objective: Studies have shown that insulin-like growth factor (IGF-I) is the main factor of growth and hypertrophy of muscle fibers. However, the effect of high-intensity interval training (HIIT) on IGF-I has not been well studied. The purpose of the present study was to investigate the changes of IGF-I gene expression in gastrocnemius muscle of male Wistar rats after a period of...

Background: Fibroblast growth factor 21 (FGF21) plays an important role in regulation of energy metabolism and insulin resistance; however, the synergistic effects of high intensity interval training (HIIT) on FGF21 and insulin resistance are not elucidated which was focused in this study. Methods: This experimental research was conducted by pretest- posttest design with control group. In this...

Introduction: Breast cancer is one of the inflammatory diseases, and physical inactivity is one of the risk factors. It has been suggested that exercise training can improve breast cancer outcomes by modulating inflammation. The aim of this study was to determine the effect of 12 weeks of high-intensity interval training and moderate- intensity continuous training on serum levels of IL-17 and I...

Introduction. The aim of this study was to investigate the effects of high fat diet-induced obesity and interval and continuous exercise training on visceral fat SIRT1 and insulin resistance in male rats.  Method. Forty male rats were divided into two groups: high-fat diet (HFD; n=32) and standard diet (C; n=8). After 10 weeks inducing obesity, eight rats from the HFD and C groups were sacrifi...

 Background: High interval training changes the bone metabolism. The present study was aimed at investigating the effect of High Intensity Interval Training (HIIT) on biochemical factor of adult male Wistar rat. Methods: In this semi-experimentral studu sixteen male Wistar rats aged 6 weeks old with weight of 250±20 g were divided into control (n=8) and experimental groups (n=8). After ...

Background and Aim: Obesity is an excessive accumulation of fat and its storage due to an imbalance between energy intake and energy consumption. High-fat diets, through inhibition of lipolysis enzymes can lead to increase in obesity and also many metabolic diseases. While exercise can activate these enzymes and lead to a change in the amount of visceral adipose tissue and reduce obesity. The p...

Background: Imbalance of apoptotic factors plays important role in pathogenesis of diabetes. Considering the role of curcumin supplementation and high-intensity interval training (HIIT) on these factors, the aim of this study was to investigate effects of four weeks of HIIT with curcumin supplementation on Bax and Bcl-2 gene expression in the soleus muscle of diabetic rats. Methods: Present st...