BACKGROUND AND THE PURPOSE OF THE STUDY The linear multivariate calibration models such as principal components regression (PCR) and partial least squares regressions (PLS1 and PLS2) due to the mathematical simplicity and physical or chemical interpretability are sufficient and generally preferred method for analysis of multicomponent drugs. In this study, simultaneous determination of paraceta...

Transmembrane proteins play vital roles in maintaining the normal cell physiology. They are also important as potential drug targets. Therefore, there is an immense academic and pharmaceutical interest in these proteins. In our lab, we have tried to use chemometric approach along with other computational and experimental methods towards elucidation of transmembrane protein structures and functi...

Today's automated laboratory instruments are capable of generating prodigious volumes of high-quality measurements. Increasingly, the powerful mathematical and statistical methods of chemometrics are being called upon to help reduce these measurements to useful information. Chemometric methods have been important in automating various data-intensive functions of the clinical laboratory, includi...

The determination of stoichiometries and stability constants of complexes by means of UV-visible spectrophotometry applying traditional methods does not evaluate the quality of the values obtained, since the classic application of these methods does not provide coverage intervals. However, the use of chemometric techniques in different steps of the application of these methods makes it possible...

This work focuses on the use of chemometric techniques for identifying activated sludge process abnormalities. Chemometric methods combined with image analysis can improve activated sludge systems monitoring and minimize the need of analytical measurements. For that purpose data was collected from aggregated and filamentous biomass, biomass composition on Gram-positive/Gram-negative bacteria an...

Identification of clay minerals based on chemometric analysis of measured infrared (IR) spectra was suggested. IR spectra were collected using the diffuse reflection technique. Discriminant analysis and principal component analysis were used as chemometric methods. Four statistical models were created for separation and identification of clay minerals. More than 50 samples of various clay miner...