Xanomeline is a novel agonist functionally selective for muscarinic receptors of the M1 subtype. It binds to this receptor in two modes, reversible and quasi-irreversible (wash-resistant). We investigated the unknown mechanism of the wash-resistant binding in experiments with muscarinic M1 receptors expressed in transfected Chinese hamster ovary cells. Xanomeline's structure consists of two het...

OBJECTIVE We aimed at examining the utility of checking and washing compulsions as markers of valid subtypes of obsessive-compulsive disorder (OCD). METHODS One hundred and six patients with obsessive-compulsive disorder were evaluated with a socio-demographic and clinical questionnaire, the Structured Clinical Interview for DSM-IV, the Yale-Brown Obsessive-Compulsive Scale, the Clinical Glob...

context blastocystis hominis is a unicellular protozoan found commonly in the intestinal tract of humans and many other animals with multiple subtypes, which tend to be specific to the host. we aimed to apply a meta-analysis for studies of protozoan pathogens in order to obtain a general overview of the prevalence and genotype analysis of blastocystis spp. in iran. results we included 40 eligib...

genomic signal processing is a relatively new field in bioinformatics, in which signal processing algorithms and methods are used to study functional structures in the dna. an appropriate mapping of the dna sequence into one or more numerical sequences enables the use of many digital signal processing tools in the analysis of different genomic sequences. also, a novel influenza a (h1n1) virus o...

Inadequate hand washing by food workers is an important contributing factor to foodborne disease outbreaks in retail food establishments (RFEs). We conducted a survey of RFEs to investigate the effect of hand washing training, availability of hand washing facilities, and the ability of the person in charge (PIC) to describe hand washing according to the Minnesota Food Code (food code) on worker...