background: although catalytic properties of different genetic polymorphisms of vkorc1 and cyp2c9 products have been identified, there is limited study available regarding warfarin dose requirement in iranian patient population. this study investigates the impact of these polymorphisms on 115 patients, referred to payvand clinical and specialty laboratory for determining the appropriate dose of...

An important complication of chemotherapy is thromboembolic events that can occur during treatment course. In this way, Warfarin can be used as an efficient prophylactic agent to prevent these complications. Although bleeding is a common adverse effect of Warfarin, eosinophilia is a rare side effect of this drug. We have reported a 5-year-old boy with Burkitt lymphoma who underwent chemotherapy...

Objective: Validation of analysis method is important, especially in analyzing narrow-index drugs such as warfarin (WF). This study aimed to obtain a validated human plasma according European Medicine Agency guidelines.
 Methods: The optimum conditions for the using fluorescence detector HPLC with Chiralcel OD-RH column (4.6 x 150 mm i.d., 5μm); guard (4.0 10 mm, 5μm), temperature 45 °C. m...

Background: To study the various factors affecting anticoagulant effect of warfarin, and to promote rational use warfarin.

  Atrial fibrillation (AF) is associated with inflammatory and hypercoagulability state. Previous studies evaluated the safety and efficacy of dabigatran and warfarin in prevention of thrombothic complications. This study was intended to assess the influence of these drugs on hemostatic and inflammatory markers among patient underwent pulmonary vein ablation.   A total of 100 patients with AF w...

  Atrial fibrillation (AF) is associated with inflammatory and hypercoagulability state. Previous studies evaluated the safety and efficacy of dabigatran and warfarin in prevention of thrombothic complications. This study was intended to assess the influence of these drugs on hemostatic and inflammatory markers among patient underwent pulmonary vein ablation.   A total of 100 patients with AF w...

apatient was admitted to the hospital because of epistaxis, ecchymoses and gum bleeding with inr of 5.5. this patient had a known case of diabetes mellitus type ii, 5 years ago. the last dose of glibenclamide for managing signs and symptoms of diabetes mellitus was 20 mg/day. her medical history also showed that last month she was diagnosed with atrial fibrillation with normal left ventricular ...