C-reactive protein (CRP) and microalbuminuria reflect intimately related components of the atherosclerotic disease process. Epidemiological studies found only modest associations between CRP and microalbuminuria. Blood pressure, one of the components of the metabolic syndrome in the general population, is the main determinant of microalbuminuria in diabetes and hypertension. We questioned wheth...

1 The central theme in case-control genetic association studies is to efficiently identify genetic markers associated with case-control status. Powerful statistical methods are critical to accomplishing this goal. A popular statistical method is the model-free Pearson's chi-square test. To achieve increased power, model-based tests have been widely used despite their lack of robustness to model...

We consider the problems of hypothesis testing and model comparison under a flexible Bayesian linear regression model whose formulation is closely connected with the linear mixed effect model and the parametric models for Single Nucleotide Polymorphism (SNP) set analysis in genetic association studies. We derive a class of analytic approximate Bayes factors and illustrate their connections with...

Objectives: To evaluate whether an antenatal and immediate postpartum Edinburgh Postnatal Depression Scale score are predictive of future postpartum depression and observe the correlation in-between the scores and associated risk factors. Methods: Study Design A survey recruiting 345 women from March 2015 to February 2016 using Edinburgh Postnatal Depression Scale for same group of individuals:...

Group Randomized Trials (GRTs) randomize groups of people to treatment or control arms instead of individually randomizing subjects. When each subject has a binary outcome, over-dispersed binomial data may result, quantified as an intra-cluster correlation (ICC). Typically, GRTs have a small number, bin, of independent clusters, each of which can be quite large. Treating the ICC as a nuisance p...