Aberrant activation of the Hedgehog (Hh) signaling pathway contributes to many forms of cancer. Primary cilia are Hh signal transduction centers. Two papers in a recent issue of Nature Medicine (Han et al., 2009; Wong et al., 2009) show that mutating cilia can increase or reduce the rates of tumorigenesis depending on how the Hh pathway is disrupted.

Commentary If there is any " sure thing " in epilepsy, the syndrome of childhood absence epilepsy (CAE) may come close to fitting the bill. The characteristic seizure semiology (staring spells), response to specific medications (ethosuximide or valproate), and prognosis (often outgrown by late adolescence) are about as close as we get to a well-defined syndrome with reproducible clinical featur...

Introduction: About 50 to 70 percent of the waste management total cost is spent on collection operations, so any little progress in reducing collection costs could significantly reduce total costs. This study aimed to analyze the collection and transportation of municipal solid waste cost in Yazd in the next 15 years. Materials and Methods: The study location (five areas) was different urban ...

Tails are of paramount importance in shaping the risk profile of portfolios with credit risk sensitive securities. In this context risk management tools require simulations that accurately capture the tails, and optimization models that limit tail effects. Ignoring the tails in the simulation or using inadequate optimization metrics can have significant effects and destroy portfolio efficiency....

To facilitate digital corporate reporting and enable computers to ‘read’ accounting information, standard-setters must construct a taxonomy assign contextual ‘metadata’ that codifies disclosures arising from concepts, standards practices. But digitalisation poses problem for reporting. Within internationally accepted practice, ‘principles-based’ give companies significant discretion in deciding...

Features| June 2023 The Gas Looks Greener on the Other Side: Using Novel Tech to Minimize Anesthesia Greenhouse Emissions Jane Ahn, MD; MD Search for other works by this author on: This Site PubMed Google Scholar Lesley A. Bennici, Ana Costa, ASA Monitor 2023, Vol. 87, 24. https://doi.org/10.1097/01.ASM.0000938828.39877.b7 Views Icon Article contents Figures & tables Video Audio Supplementary D...