Age-related macular degeneration (AMD) and cataract are common age-related diseases in humans. Previously we showed that senescence-accelerated OXYS rats develop retinopathy and cataract, which are comparable to human AMD and senile cataract. Here we focused on the identification of quantitative trait loci (QTLs), which affect early-onset cataract and retinopathy in OXYS rats, using F2 hybrids ...

WAG/Rij rats are genetic animal model of absence epilepsy with comorbidity of depression. The first spike-wave discharges (SWDs) in WAG/Rij rats begin to appear at the age of 2-3 months and are fully manifested by 5-6 months. Occurrence of SWDs in the EEG is the main index of absence epilepsy. Previously it has been shown that the extensive absence epilepsy in 5-6 months old WAG/Rij rats is acc...

Haloperidol treatment during pre- and post-natal period affects maternal behavior and this may have long-term effects on the offspring. We examined whether early haloperidol administration to Wistar-Albino-Glaxo dams from Rijswijk (WAG/Rij) and in Wistar control rats would affect maternal care and as a consequence, seizure susceptibility and behavior in the WAG/Rij's offspring at 3-4 months of ...

Carbon dioxide has been used commercially to recover oil from reservoirs for more than 40 years. Currently, CO2 flooding is the second most applied enhanced oil recovery (EOR) process in the world behind steam flooding. Water alternating gas (WAG) injection has been a popular method to control mobility and improve volumetric sweep efficiency for CO2 flooding. Average EOR is about 9.7% with a ra...

PURPOSE To study the effect of the antiepileptic drug levetiracetam (LEV) on the patterns of intrinsic optical signals (IOSs) generated by slices of the somatosensory cortex obtained from 3- and 6-month-old WAG/Rij and age-matched, nonepileptic control (NEC) rats. METHODS WAG/Rij and NEC animals were anesthetized with enfluorane and decapitated. Brains were quickly removed, and neocortical sl...

A 2-yr study was conducted to evaluate 1) steers fed ad libitum high concentrate after weaning (CONC), or 2) steers grown on pasture for 82 d, followed by high-concentrate finishing (PAST), on the performance and carcass traits of 74 early-weaned (117 d of age) steers. Potential breed differences were evaluated using crossbred steers of three types: 1) 3/4 Angus x 1/4 Simmental (BRI), 2) 3/4 Si...

Amino acid replacement matrices are an essential basis of protein phylogenetics. They are used to compute substitution probabilities along phylogeny branches and thus the likelihood of the data. They are also essential in protein alignment. A number of replacement matrices and methods to estimate these matrices from protein alignments have been proposed since the seminal work of Dayhoff et al. ...

Potential health hazards from waste anesthetic gases (WAGs) have been a concern since the introduction of inhalational anesthetics into clinical practice. The potential to exceed recommended exposure levels (RELs) in the postanesthesia care unit (PACU) exists. The aim of this pilot study was to assess sevoflurane WAG levels while accounting for factors that affect inhalational anesthetic elimin...

s | 23 investigate the efficacy of ETX treatment on absence seizures and its effect on potentially observable cardiovascular changes in genetic absence epileptic WAG/Rij rats. Method: We divided 2-month-old Wistar and WAG/Rij rats into two groups (n=16): Control and ETX groups. The ETX groups were treated with ETX (orally, 300 mg/kg/day) for 3 months. Control groups received physiological salin...

Abstract Flue gas flooding is one of the important technologies to improve oil recovery and achieve greenhouse storage. In order study multicomponent flue storage capacity enhanced (EOR) performance water-alternating (flue gas–WAG) injection after continuous waterflooding in an reservoir, a long core system was built. The experimental results showed that factor gas–WAG increased by 21.25% could...