Regeneration and functional recovery of the hypothalamoneurohypophysial system (HNS) in neurohypophysectomized rats treated with either saline or vasopressin (VP) were analyzed utilizing specific immunohistochemical and physiological measures. Neural lobe ablation combined with VP administration precipitated a profound diabetes insipidus (following cessation of VP delivery) that persisted for t...

The present study sought to determine whether an acute increase in arterial blood pressure (ABP) reduces plasma vasopressin (VP) levels stimulated by ANG II or hyperosmolality. During an intravenous infusion of ANG II (100 ng.kg(-1).min(-1)), attenuation of the ANG II-evoked increase in ABP with diazoxide or minoxidil did not further enhance plasma VP levels in rats. When VP secretion was stimu...

The effects of microtubule inhibitors on cellular accumulation of 4'demethylepipodophyIlotoxin-9-(4,6-0-ethyIidine-/î-D-glucopyranoside) (VP-16) and subsequent epipodophyllotoxin-induced DNA single-strand breaks were investigated in human leukemia K562 cells. At concentra tions of 0.05-20 MM.vinblastine, vincristine, and maytansine similarly increased the steady-state cell concentration of VP-...

In the generative literature, clause type effects have typically been modeled in one of two ways—“truncation” whereby embedded clauses are structurally reduced relative to root clauses, and intervention, by which non-root clauses have additional material that blocks movement available in root contexts. This paper analyzes two clause type effects in Basque— the possibility of verb-initial word o...

The effects of microtubule inhibitors on cellular accumulation of 4'-demethylepipodophyllotoxin-9-(4,6-O-ethylidine-beta-D-glu copyranoside) (VP-16) and subsequent epipodophyllotoxin-induced DNA single-strand breaks were investigated in human leukemia K562 cells. At concentrations of 0.05-20 microM, vinblastine, vincristine, and maytansine similarly increased the steady-state cell concentration...

The primary objective of this study was to compare the pharmacokinetics of a new anti-human immunodeficiency virus agent 1-(2-amino-pyridin-4-ylmethyl)-6-(3,5-dimethylbenzoyl)-5-isopropyl-1H-pyrimidine-2,4-dione (VP-0502) with its amino acid prodrug alanine amide of VP-0502 (VP-0502AL), following intravenous and oral administrations to rats. The plasma concentrations of both analytes were analy...

SUMMARY BACKGROUND: We aimed to evaluate the anxiety of patients receiving orthodontic treatment during COVID-19 pandemic. METHODS: A 27-questions online questionnaire form was designed assess patients’ levels regarding pandemic with Google Forms (Google LLC, Mountain View,CA,ABD). The link sent 400 and study conducted 262 volunteer patients(VP) who were active agreed fill out our voluntarily. ...

Verapamil (VP) is used as a racemate but shows stereoselective pharmacokinetics and pharmacodynamics. It undergoes extensive first-pass metabolism. Stereoselective first-pass metabolism in the intestine and liver was investigated in vivo and in vitro to determine its impact on the disposition of VP and its main metabolite, norverapamil (NVP). VP racemate was administered to rats i.v., p.o., and...

BACKGROUND Prolonged pleural effusion following Fontan operation is common and increases morbidity and hospital length of stay. Vasopressin (VP), a neurohypophysial hormone, has numerous effects on the cardiovascular system. The most notable is increased peripheral vascular resistance, but it may also reduce capillary leakage by tightening endothelial intercellular junctions and reducing capill...