Herein, we describe a fast and robust method for achieving (68)Ga-labelling of the EGFR-selective monoclonal antibody (mAb) Cetuximab using the bioorthogonal Inverse-electron-Demand Diels-Alder (IeDDA) reaction. The in vivo imaging of EGFR is demonstrated, as well as the translation of the method within a two-step pretargeting strategy.

background: based on recent studies, there are controversial reports on the ca-pacity of tissue cyst forming of toxoplasma gondii rh strain. in this study, the capac-ity was evaluated by in vivo and in vitro experiments. methods : rh strain was subcutaneously inoculated to ten wistar rats. after one month, their blood, brain, tongue and diaphragm were collected and evaluated by mat, pcr, pathol...

objective(s):  the field of nanotechnology is rapidly expanding .the development quantum dots quantum dot (qds), show great promise for treatment and diagnosis of cancer and targeted drug delivery little data on the toxicity of qds, especially for in vivo applications, are available. as a result, concerns exist over their toxicity for in vivo applications. then, cytotoxic effects of cadmium sel...

abstract background: in vivo measurements of applied dose during radiotherapy treatment, is important to ensure accurate dose delivery to patients. uncertainty in dose delivery should fall within ±5% of the prescribed dose as recommended by icru. assessment of dose for radiotherapy applications performed with various types of detectors. in this study, semiconductor diodes were used which have s...

background: delivering the maximum dose to tumor while achieving the minimum dose delivery to normal tissue; is the most important goal in external radiotherapy. diode in vivo dosimetry is widely considered to be an important tool for quality improvement of patient care in external radiotherapy. uncertainty in dose delivery should fall within 5% of the prescribed dose as recommended by internat...

introduction: during radiotherapy, high accuracy in the dose delivery is required because there is a strong  relationship between the absorbed dose, local tumor control and particularly the normal tissue damage. in  many institutions, in vivo dosimetry using diodes is performed to check the actual dose delivered. in general,  the uncertainty in the dose delivered should fall within  ± 5% of the...

background: in leishmaniasis, some drugs prescribed for treatment have toxic ef-fects and there are reports about drug resistance in some countries. due to this fact, using herbal drugs such as artemisinin with good efficacy and low toxic effect might be suitable. methods: we evaluated the apoptotic effect of artemisinin on leishmania major in vitro and the antileishmanial activities of artemis...

background: toxoplasma gondii is the most common parasite causing latent cerebral infections in human. it has been shown that some anti-psychotic drugs are able to inhibit the proliferation of the parasite in in vitro study. there is very limited data regarding the inhibitory effect of anti-psychotics on toxoplasma in in vivo . in this study, we evaluated anti- toxoplasma activity of fluphenazi...