Students of the vitamin B complex now agree on the existence of two physiologically active components, vitamin B1 (B) and vitamin B2 (G).4 From time to time experimental evidence has been presented indicating that these two alone cannot account for all of the properties of the old B complex.8 We present in this paper evidence that a "third factor" is associated with vitamin B1 (B) in a concentr...

Approximately one-quarter of circulating cobalamin (vitamin B-12) binds to transcobalamin (holoTC) and is thereby available for the cells of the body. For this reason, holoTC is also referred to as active vitamin B-12. HoloTC was suggested as an optimal marker of early vitamin B-12 deficiency >20 y ago. This suggestion led to the development of suitable assays for measurement of the compound an...

According to Stedman's Medical Dictionary, a vitamin is 'one of a group of organic substances, present in minute amounts in natural foodstuffs, that are essential to normal metabolism.' As defined, vitamins are present in very small quantities in most foods and it is this fact that leads to the manufacture of vitamin supplements for dogs, cats, and people. Not only are vitamins naturally presen...

In previous experiments,2 an unsuccessful attempt was made to acclimate monkey cord virus to white rats, which had been made completely vitamin B1 deficient by feeding them a vitamin B1 free diet for 30 days prior to the start of the experiment. It was thought that our failure might have been due to the fact that we did not have the animals in a proper state or stage of deficiency; perhaps the ...