background more than two billion people have been exposed to hepatitis b virus (hbv) worldwide. furthermore, four hundred million of them are infected with chronic hbv infection. the predominant mutation of the precore region involves a g to a change at nucleotide1896, which creates a premature stop codon at codon 28. two mutations of a1762t and g1764a are reported as the most prevalent mutatio...

background: serial measurement of  hepatitis b virus (hbv) dna levels in the liver and its relation with liver damage and serum hbv dna levels are guide to begin and/or end a treatment course. this study evaluated the relationship between liver hepatitis b dna viral load with liver histology in patients with chronic hepatitis b (hbv). methods:  thirty patients with chronic anti-hbe positive hep...

background: viral load and alanine aminotransferase (alt) levels may not be the key points for making a decision in the treatment of anti-hbe positive chronic hepatitis b. the purpose of this study was to assess the histological evaluation of liver to find the need for treatment on 72 patients with anti-hbe positive chronic hepatitis b. methods: the liver biopsy slides of the 72 patients (56 su...

background diagnosis and control programs for infectious diseases among immigrants are the most important aspects of epidemiological studies for both origin and destination countries. data about hepatitis b virus (hbv) infection among the afghan immigrants in iran is limited. objectives to the best of hbv treatment and prevention in afghan immigrants in iran, the present study was conducted to ...

background although certain hbv mutations are known to affect the expression of hepatitis e antigen, their association with hbv viral level or clinical outcomes is less clear. objectives we evaluated associations between different mutations in the basal core promoter (bcp) and pre-core (pc) regions of hbv genome and subsequent changes in hbv viral dna level over seven years in a population of u...

background hepatitis c virus (hcv) infection is one the major health concern among the infected transplant patients. considering several complications of the disease in them, pre and post-transplantation studies should be performed for monitoring of the infection, as well as, developing new treatment protocols. objectives the current study was conducted to determine the hepatitis c virus rna le...

introduction: occurrence of detectable amounts of viral antigen or viral particles in the blood of infected patients with hepatitis b virus (hbv) is a significant characteristic of hbv infection. detection of hbv antigen or its dna among individuals of a community is a crucial factor to know the burden of hbv infection. hepatitis b surface antigen (hbsag) is a suitable marker of hbv infection b...

Introduction: Hepatitis B and C are major health problems in many countries, especially developing areas. The frequency of hepatitis B is less than 0.8%, and chronic hepatitis C is less than 0.5% in the general population of Yazd in the center of Iran. Large vehicle drivers have some risk factors for acquiring hepatitis B and C infection. This is important because viral hepatitis complications,...

Background: Hepatitis activity index (HAI) and fibrosing stage are two important findings during the evaluation of liver samples in patients with chronic hepatitis B. The aim of this study was to determine the HAI and fibrosing stage in patients with anti-HBe positive chronic hepatitis B. Methods: Liver biopsy slides of 72 patients were evaluated at the Department of Pathology in two teaching ...