Increasingly restrictive emission regulations and renewed focus on energy efficiency drive the current researches to find alternative fuels and their related better combustion strategies. In this regard, dual fuel engines, in which natural gas fuel is used as a main fuel and diesel fuel is employed as a pilot fuel, have received considerable attention. However, poor fuel utilization efficiencie...

The C(2)H(2) zinc-finger transcription factor Egr-1 has previously been shown to play an essential role within the endocrine system as a molecular determinant of LH beta-subunit synthesis in anterior pituitary gonadotrophs. The extent to which Egr-1 may be a dynamic mediator of changes in gonadotroph function during the oestrous cycle is currently unclear. We have recently produced a novel rat ...

BACKGROUND The factors that influence nocturnal compliance among patients prescribed low flow oxygen therapy were determined and tolerance of nasal cannulae and Venturi face masks compared. METHODS Two studies were performed: (1) a prospective study of 99 hospitalised patients prescribed low flow oxygen therapy, 49 on nasal cannulae and 50 on Venturi face mask; and (2) a prospective study of ...

This study investigates how high levels of exhaust gas recirculation (EGR) combined with certain fuel injection strategies and energy recovery systems affect diesel engine emissions and fuel economy. The key test apparatus was a John Deere 4.5L diesel engine which was modeled using the computer-based engine simulation tool GT-Power. The conclusion was made that utilization of high EGR levels (3...

Among all known angiogenic molecules, vascular endothelial growth factor (VEGF) is probably the most extensively characterized growth factor that displays broad vascular functions including vasculogenesis, angiogenesis, vascular permeability, vascular survival, and vascular remodeling.1,2 These vascular functions of VEGF are mainly mediated by VEGF tyrosine kinase receptors (TKRs) expressed in ...

Differentiation of osteoclasts is defined by the transcription factors expressed in response to bone microenvironments. In this work, we examined the effects of an expressional blockage of Egr-1 and/or WT1 on the differentiation of osteoclasts using specific antisense oligodeoxynucleotides (ODN). In a culture system forming preosteoclast-like cells (POC) from rat bone marrow cells depleted of m...

Early Growth response-1 (Egr-1) is a transcription factor that possesses a variety of biological functions. It has been shown to regulate HSV-1 gene expression and replication in different cellular environments through the recruitment of distinct cofactor complexes. Previous studies demonstrated that Egr-1 can be induced by HSV-1 infection in corneal cells but the level was lower compared to ot...

Monitoring the flow rate out of the well is critical for good control of the downhole pressure in drilling operations. In this feasibility study, we explore the possibility of using a Venturi flume to provide a cost-effective measurement of the flow rate, with improved accuracy compared to conventional methods. A Venturi flume has been simulated both using CFD and a simplified 1D model. By prop...

Legislators steadily increase the demands on lowered emissions from heavy duty vehicles. To meet these demands it is necessary to integrate technologies like Exhaust Gas Recirculation (EGR) and Variable Geometry Turbochargers (VGT) together with advanced control systems. Control structures are proposed and investigated for coordinated control of EGR valve and VGT position in heavy duty diesel e...

We have previously reported that the exposure of human HepG2 cells to hypoxic conditions results in the overexpression of human insulin-like growth factor II (IGF-II) mRNA whose size is 6.0 kb. This particular size of IGF-II mRNA is transcribed under the control of the IGF-II P3 promoter. In the present study, to delineate the molecular mechanism for the activation of the IGF-II gene, we examin...